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Titolo:
NOVEL HEXARELIN ANALOGS STIMULATE FEEDING IN THE RAT THROUGH A MECHANISM NOT INVOLVING GROWTH-HORMONE RELEASE
Autore:
TORSELLO A; LUONI M; SCHWEIGER F; GRILLI R; GUIDI M; BRESCIANI E; DEGHENGHI R; MULLER EE; LOCATELLI V;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,DEPT PHARMACOL I-20129 MILAN ITALY EUROPEPTIDES ARGENTEUIL FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 360, anno: 1998,
pagine: 123 - 129
SICI:
0014-2999(1998)360:2-3<123:NHASFI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC HEXAPEPTIDE; INFANT RATS; FOOD-INTAKE; NORMAL MEN; PEPTIDE; RECEPTOR; SECRETAGOGUES; PITUITARY; RESPONSES; INVITRO;
Keywords:
HEXARELIN; GHRP (GROWTH HORMONE-RELEASING PEPTIDE); GK (GROWTH HORMONE)-SECRETAGOGUE; FEEDING; GH (GROWTH HORMONE) SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Torsello et al., "NOVEL HEXARELIN ANALOGS STIMULATE FEEDING IN THE RAT THROUGH A MECHANISM NOT INVOLVING GROWTH-HORMONE RELEASE", European journal of pharmacology, 360(2-3), 1998, pp. 123-129

Abstract

Growth hormone-releasing peptides (GHRPs) are a class of small peptides that stimulate growth hormone (GH) release in several animal species, including the human. Moreover, GHRPs injected into the brain ventricles stimulate feeding in the rat. The aim of this study was to evaluate the GH-releasing properties of a series of novel GHRP analogs and the possible existence of functional correlations between the GH-releasing activity and the effects on feeding behavior. Two well-known hexapeptides, GHRP-6 and hexarelin, given s.c., dose dependently stimulatedboth GH release and feeding behavior in satiated rats. However, in a series of tri-, penta- and hexapeptide analogs of hexarelin, some compounds were active either on GH release or on eating behavior. Interestingly, even minor structural modifications resulted in major changes of the pharmacological profile. We conclude that GHRPs have orexigenic properties after systemic administration which are largely independentfrom the effects they exert on GH release. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 12:46:42