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Titolo:
INTERACTION OF EXERCISE TRAINING AND CHRONIC ETHANOL INGESTION ON TESTICULAR ANTIOXIDANT SYSTEM IN RAT
Autore:
HUSAIN K; SOMANI SM;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL,POB 19230 SPRINGFIELD IL 62794 SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL SPRINGFIELD IL 62794
Titolo Testata:
Journal of applied toxicology
fascicolo: 6, volume: 18, anno: 1998,
pagine: 421 - 429
SICI:
0260-437X(1998)18:6<421:IOETAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICALS; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; LIVER-MICROSOMES; DIFFERENTIAL REGULATION; RESISTANCE EXERCISE; ALCOHOL; RESPONSES; INJURY; TESTOSTERONE;
Keywords:
ETHANOL; ANTIOXIDANT ENZYMES; EXERCISE TRAINING; TESTES; GLUTATHIONE; LIPID PEROXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
K. Husain e S.M. Somani, "INTERACTION OF EXERCISE TRAINING AND CHRONIC ETHANOL INGESTION ON TESTICULAR ANTIOXIDANT SYSTEM IN RAT", Journal of applied toxicology, 18(6), 1998, pp. 421-429

Abstract

Recent evidence has indicated that exercise as well as ethanol exertsoxidative stress on vital organs/tissues of the body. However, the combination of both on the testicular antioxidant system is not known, This study investigates the interactive effects of exercise training and chronic ethanol ingestion on the testicular antioxidant system in rats. Male Fisher-344 rats were treated as follows: sedentary control (SC); exercise training (ET) for 6.5 weeks; ethanol (2 g kg(-1), p.o.) for 6.5 weeks; and ET plus ethanol for 6.5 weeks, Exercise training significantly decreased copper-zinc superoxide dismutase (CuZn-SOD) activity and enzyme protein concentration (73% and 67% of SC), whereas manganese SOD (Mn-SOD) and catalase (CAT) activity significantly increased(157% and 141% of SC) in the testes of rat, Exercise training significantly decreased the testicular malondialdehyde (MDA) concentration (70% of SC). Chronic ethanol ingestion significantly decreased testicular CuZn-SOD activity, enzyme protein concentration and CAT activity (65, 70 and 47% of SC) in rats. Ethanol significantly increased the testicular MDA level (129% of SC). The combination of exercise training andchronic ethanol ingestion significantly decreased testicular CuZn-SODprotein, MDA and the reduced glutathione oxidized glutathione ratio (GSH/GSSG) by 62, 70 and 79%, respectively. The data suggest that exercise training provides protection whereas chronic ethanol ingestion exerts oxidative damage to the testes of rat, Exercise training seems to reduce the extent of oxidative damage caused by ethanol on the testes of rats. (C) 1998 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:07:21