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Titolo:
THYROID-DYSFUNCTION AND NODULAR GOITER IN HEMODIALYSIS AND PERITONEAL-DIALYSIS PATIENTS
Autore:
LIN CC; CHEN TW; NG YY; CHOU YH; YANG WC;
Indirizzi:
VET GEN HOSP,DEPT MED,DIV NEPHROL,NO 201,SEC 2,SHIH PAI RD TAIPEI 112TAIWAN VET GEN HOSP,DEPT MED,DIV NEPHROL TAIPEI 112 TAIWAN VET GEN HOSP,DEPT RADIOL,DIV ULTRASOUND TAIPEI TAIWAN NATL YANG MING UNIV,SCH MED TAIPEI 112 TAIWAN
Titolo Testata:
Peritoneal dialysis international
fascicolo: 5, volume: 18, anno: 1998,
pagine: 516 - 521
SICI:
0896-8608(1998)18:5<516:TANGIH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; MAINTENANCE HEMODIALYSIS; CYTOKINE PRODUCTION; HYPOTHYROIDISM; INTERLEUKIN-1; MEMBRANES; HORMONES; DISEASE; ALPHA;
Keywords:
GOITER; THYROID DYSFUNCTION; END-STAGE RENAL DISEASE; HEMODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Lin et al., "THYROID-DYSFUNCTION AND NODULAR GOITER IN HEMODIALYSIS AND PERITONEAL-DIALYSIS PATIENTS", Peritoneal dialysis international, 18(5), 1998, pp. 516-521

Abstract

Objective: To investigate the prevalence of nodular goiter and thyroid dysfunction in uremic patients undergoing hemodialysis (HD) and peritoneal dialysis. Design: Cross-sectional study. Setting: Single dialysis unit and outpatient clinic. Patients:The study included 221 patients [143 HD and 78 continuous ambulatory peritoneal dialysis (CAPD) patients] along with 135 consecutively selected outpatients as controls. Main Outcome Measures: Ultrasonography was used to detect patients' thyroid function and nodular goiter. Results: Nodular goiter was detectedin 54.8% of the uremic patients and in 21.5% of the controls. Uremic patients had higher prevalence of thyroid dysfunction, which included reduced serum concentration of total T3, total T4, and free T4, and increased serum level of TSH. Hypothyroidism was also observed more frequently in uremic patients than in the control group (5.4% vs 0.7%, p <0.05). Nodular goiter was more frequently found in females than in males (63.5% vs 48%, p < 0.05). Moreover, the prevalence of nodular goiter increased with age (p < 0.02) in uremic patients. Hemodialysis patients had a higher frequency of reduced total T3 level (46.9% vs 29.5%,p < 0.02). However, CAPD patients had lower T4 levels (6.23 +/- 1.82 mu g/dL vs 7.15 +/- 1.99 mu g/dL, p < 0.05).Conclusion: Because of thehigh incidence of hypothyroidism and nodular goiter in uremic patients, screening of thyroid function and goiter detection with ultrasound should be considered in evaluation of end-stage renal disease patients.

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Documento generato il 26/01/20 alle ore 09:58:40