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Titolo:
TENASCIN-C EXPRESSION IN INVASION BORDER OF EARLY BREAST-CANCER - A PREDICTOR OF LOCAL AND DISTANT RECURRENCE
Autore:
JAHKOLA T; TOIVONEN T; VIRTANEN I; VONSMITTEN K; NORDLING S; VONBOGUSLAWSKI K; HAGLUND C; NEVANLINNA H; BLOMQVIST C;
Indirizzi:
UNIV HELSINKI,CENT HOSP,DEPT SURG 4,KASARMIKATU 11-13 FIN-00130 HELSINKI FINLAND UNIV HELSINKI,DEPT SURG 4 FIN-00130 HELSINKI FINLAND KYMENLAAKSO CENT HOSP,DEPT PATHOL FIN-48210 KOTKA FINLAND UNIV HELSINKI,HAARTMAN INST,INST BIOMED,DEPT ANAT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,HAARTMAN INST,DEPT PATHOL FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT SURG 2 FIN-00290 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT OBSTET & GYNECOL FIN-00290 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT ONCOL FIN-00290 HELSINKI FINLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 11, volume: 78, anno: 1998,
pagine: 1507 - 1513
SICI:
0007-0920(1998)78:11<1507:TEIIBO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CLINICAL-TRIAL; S-PHASE FRACTION; PROGNOSTIC FACTORS; CONSERVATIVE SURGERY; RADIATION-THERAPY; FLOW-CYTOMETRY; RISK-FACTORS; CARCINOMA; RADIOTHERAPY; MARKER;
Keywords:
TENASCIN-C; EARLY BREAST CANCER; METASTASIS; BREAST-CONSERVING SURGERY; LOCAL RECURRENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Jahkola et al., "TENASCIN-C EXPRESSION IN INVASION BORDER OF EARLY BREAST-CANCER - A PREDICTOR OF LOCAL AND DISTANT RECURRENCE", British Journal of Cancer, 78(11), 1998, pp. 1507-1513

Abstract

We have recently demonstrated an association between distant metastasis and the expression of the extracellular matrix glycoprotein tenascin-C (Tn-C) in the invasion border of small axillary node-negative breast carcinomas. Our purpose was to assess the relationship between the expression of Tn-C in the tumour invasion border and several histopathological and biological variables and to compare their usefulness in predicting local and distant disease recurrences. The original patient group consisted of 143 women with axillary node-negative breast cancer(one bilateral) treated with breast-conserving surgery and post-operative radiotherapy, and followed for a median of 8 years. Because of the small number of recurrences an additional group of 15 similarly treated women with recurrent breast cancer was also studied. The size of the tumour, its histology, including a possible intraductal component, and grade were re-evaluated. The expression of erbB-2, p53, Ki-67 and Tn-C was evaluated by immunohistochemistry. Ploidy and S-phase fraction (SPF) were assessed by flow cytometry. The only statistically significant prognostic factor for local recurrence was Tn-C expression in the invasion border. For metastasis Ki-67 positivity, tumour size and Tn-C expression in the invasion border were statistically significant, but Ki-67 positivity was the only independent prognostic factor. Tn-C expression in the invasion border was associated with a higher proliferation rate measured by Ki-67 and SPF, which is consistent with the suggested growth-promoting activity of Tn-C. Tn-C may be a useful marker in selecting patients for adjuvant therapies to reduce the rate of both local and distant cancer recurrences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:41:53