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Titolo:
THE EFFECTS OF HOST CARBOGEN (95-PERCENT OXYGEN 5-PERCENT CARBON-DIOXIDE) BREATHING ON METABOLIC CHARACTERISTICS OF MORRIS-HEPATOMA-9618A
Autore:
STUBBS M; ROBINSON SP; RODRIGUES LM; PARKINS CS; COLLINGRIDGE DR; GRIFFITHS JR;
Indirizzi:
UNIV LONDON ST GEORGES HOSP,SCH MED,DIV BIOCHEM,CRC BIOMED MR RES GRP,CRANMER TERRACE LONDON SW17 0RE ENGLAND MT VERNON HOSP,GRAY LAB CANC RES TRUST,TUMOUR MICROCIRCULAT GRP NORTHWOOD HA6 2JR MIDDX ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 11, volume: 78, anno: 1998,
pagine: 1449 - 1456
SICI:
0007-0920(1998)78:11<1449:TEOHC(>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; TUMOR BLOOD-FLOW; RADIATION RESPONSE; NORMOBARIC OXYGEN; PH GRADIENT; RAT-TUMORS; P-31 MRS; LACTATE; HYPOXIA; CANCER;
Keywords:
METABOLIC PROFILE; HEPATOMA; PH; PO(2); P-31 MAGNETIC RESONANCE SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M. Stubbs et al., "THE EFFECTS OF HOST CARBOGEN (95-PERCENT OXYGEN 5-PERCENT CARBON-DIOXIDE) BREATHING ON METABOLIC CHARACTERISTICS OF MORRIS-HEPATOMA-9618A", British Journal of Cancer, 78(11), 1998, pp. 1449-1456

Abstract

Characteristics of the tumour metabolic profile play a role in both the tumour-host interaction and in resistance to treatment. Because carbogen (95% oxygen/5% carbon dioxide) breathing can both increase sensitivity to radiation and improve chemotherapeutic efficacy, we have studied its effects on the metabolic characteristics of Morris hepatoma 9618a. Host carbogen breathing increased both arterial blood pCO(2) andpO(2), but decreased blood pH. A fourfold increase in tumour pO(2) (measured polarographically) and a twofold increase in image intensity [measured by gradient recalled echo magnetic resonance (MR) imaging sensitive to changes in oxy/deoxyhaemoglobin] were observed. No changes were seen in blood flow measured by laser Doppler flowmetry. Tumour intracellular pH remained neutral, whereas extracellular pH decreased significantly (P < 0.01). Nucleoside triphosphate/inorganic phosphate (NTP/P-i), tissue and plasma glucose increased twofold and lactate decreased in both intra- and extracellular compartments, suggesting a changeto a more oxidative metabolism. The improvement in energy status of the tumour was reflected in changes in tissue ions, including Nat, through ionic equilibria. The findings suggest that the metabolic profile of hepatoma 9618a is defined partly by intrinsic tumour properties caused by transformation and partly by tissue hypoxia, but that it can respond to environmental changes induced by carbogen with implications for improvements in therapeutic efficacy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:19:52