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Titolo:
URINARY ENDOTHELIN-1 IN PATIENTS WITH RENAL-DISEASE
Autore:
CHU TS; WU MS; HSIEH BS;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,7 CHUNG SHAN S RD TAIPEI 100 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED TAIPEI TAIWAN
Titolo Testata:
Journal of the Formosan Medical Association
fascicolo: 10, volume: 97, anno: 1998,
pagine: 667 - 672
SICI:
0929-6646(1998)97:10<667:UEIPWR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBULAR EPITHELIAL-CELLS; VASOCONSTRICTOR PEPTIDE; PLASMA; EXCRETION; HYPERTENSION; EXPRESSION; BETA; GENE;
Keywords:
ENDOTHELIN-1; GLOMERULONEPHRITIS; CHRONIC RENAL FAILURE; BETA(2)-MICROGLOBULIN; RENAL TUBULE; SODIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T.S. Chu et al., "URINARY ENDOTHELIN-1 IN PATIENTS WITH RENAL-DISEASE", Journal of the Formosan Medical Association, 97(10), 1998, pp. 667-672

Abstract

The purpose of this study was to investigate the usefulness of urinary endothelin-l (ET-1) as a marker of renal disease. We measured urinary excretion of ET-1 in 28 patients with glomerulonephritis (GN), 22 patients with chronic renal failure (CRF), 40 patients with end-stage renal disease (ESRD), and 17 healthy volunteers. There was no significant difference in 24 hour urinary ET-I excretion among the four groups (mean +/- SEM, 0.49 +/- 0.22 ng in controls, 0.79 +/- 0.37 ng in GN patients, 0.39 +/- 0.18 ng in CRF patients, and 0.28 +/- 0.11 ng in ESRD patients). The 24-hour urinary excretion of ET-1 in patients with GN or CRF showed significant correlation with the urinary excretion of sodium (r = 0.27, p < 0.05). The 24-hour urinary beta(2)-microglobulin (beta(2)M) excretion in patients with CRF (18.4 +/- 2.6 mg) or ESRD (9.7+/- 1.1 mg) was significantly higher than in normal control subjects (0.23 +/- 0.11 mg). Serum creatinine concentration was positively correlated with the 24-hour urinary excretion of beta(2)M in patients withGN or CRF(r = 0.50, P < 0.001). These findings indicate that urinary ET-1 is not as good a marker of renal disease as urinary beta(2)M. However, it may be responsible for urinary sodium excretion in patients with GN Or CRF.

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Documento generato il 29/03/20 alle ore 17:16:38