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Titolo:
SINGLE AMINO-ACID CHANGE IN DNA-POLYMERASE IS ASSOCIATED WITH FOSCARNET RESISTANCE IN A VARICELLA-ZOSTER VIRUS-STRAIN RECOVERED FROM A PATIENT WITH AIDS
Autore:
VISSE B; DUMONT B; HURAUX JM; FILLET AM;
Indirizzi:
HOP LA PITIE SALPETRIERE,CERVI,VIROL LAB,83 BLVD DE HOP F-75651 PARISFRANCE HOP LA PITIE SALPETRIERE,CERVI,VIROL LAB F-75651 PARIS FRANCE
Titolo Testata:
The Journal of infectious diseases
, volume: 178, anno: 1998, supplemento:, 1
pagine: 55 - 57
SICI:
0022-1899(1998)178:<55:SACIDI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CYTOMEGALOVIRUS; POINT MUTATION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
B. Visse et al., "SINGLE AMINO-ACID CHANGE IN DNA-POLYMERASE IS ASSOCIATED WITH FOSCARNET RESISTANCE IN A VARICELLA-ZOSTER VIRUS-STRAIN RECOVERED FROM A PATIENT WITH AIDS", The Journal of infectious diseases, 178, 1998, pp. 55-57

Abstract

The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. Compared with the sequence of the Dumas reference strain, this strain, which was isolated from a patient in whom foscarnet treatment failed, had two point mutations. The emergence of one of the mutations, which includes a change from a glutamic acid to a lysine at position 512 in the DNA polymerase, suggests that this mutation is implicated in the VZV foscarnet resistance. The other mutation, which replacesserine 863 by a glycine, is also present in 2 susceptible strains-Okaand a wild-type isolate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:11:02