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Titolo:
BIMODAL ACTION OF FUROSEMIDE ON CONVULSANT [H-3]EBOB BINDING TO CEREBELLAR AND CORTICAL GABA(A) RECEPTORS
Autore:
MAKSAY G; KORPI ER; UUSIOUKARI M;
Indirizzi:
UNIV TURKU,DEPT PHARMACOL & CLIN PHARMACOL FIN-20520 TURKU FINLAND UNIV TURKU,DEPT PHARMACOL & CLIN PHARMACOL FIN-20520 TURKU FINLAND HUNGARIAN ACAD SCI,CENT RES INST CHEM H-1525 BUDAPEST HUNGARY
Titolo Testata:
Neurochemistry international
fascicolo: 4, volume: 33, anno: 1998,
pagine: 353 - 358
SICI:
0197-0186(1998)33:4<353:BAOFOC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINOBUTYRIC ACID(A) RECEPTORS; GATED CHLORIDE CHANNEL; )S-35>TBPS BINDING; HIGH-AFFINITY; TBPS BINDING; BRAIN; SITES; MODULATION; COMPLEX; CORTEX;
Keywords:
CONVULSANT (EBOB) BINDING; CEREBELLUM; GABA(A) RECEPTOR; FUROSEMIDE; NIFLUMATE; PENTOBARBITAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G. Maksay et al., "BIMODAL ACTION OF FUROSEMIDE ON CONVULSANT [H-3]EBOB BINDING TO CEREBELLAR AND CORTICAL GABA(A) RECEPTORS", Neurochemistry international, 33(4), 1998, pp. 353-358

Abstract

Picrotoxinin-sensitive binding of a convulsant ethynyl-4-n[2,3-H-3(2)]Propyl-bicycloorthobenzoate ([H-3]EBOB) to gamma-amino butyric acid type A (GABA(A)) receptors was characterized in rat cerebrocortical andcerebellar membranes. The non-penetrating organic anions, furosemide and niflumate, in spite of their structural similarities, exerted differential effects on [H-3]EBOB binding. Furosemide, a loop diuretic anda specific antagonist of a cerebellar GABA(A) receptor population, and GABA decreased the inhibitory potencies of each other in the cerebellum while enhanced them in the cortex. The inhibitory potencies of niflumate, an anti-inflammatory and a chloride channel blocker, and GABA were enhanced by each other both in the cerebellum and cortex. Removalof chloride ions did not modify the effects of furosemide on [H-3]EBOB binding. Furosemide antagonized the inhibition of cerebellar [H-3]EBOB binding by a low pentobarbital concentration (0.1 mM), but enhancedthe inhibition by a high concentration (0.5 mM). The results indicatethat [H-3]EBOB binding can be used to detect the known pharmacological features of the cerebellar granule cell-specific alpha 6 subunit-containing GABA(A) receptors. The data extends the properties of furosemide antagonism of this receptor subtype to chloride insensitivity and interactions with barbiturate sites. (C) 1998 Elsevier Science Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:16:42