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Titolo:
COMPLEX-FORMATION OF THE NONSTRUCTURAL PROTEIN-3 OF HEPATITIS-C VIRUSWITH THE P53 TUMOR-SUPPRESSOR
Autore:
ISHIDO S; HOTTA H;
Indirizzi:
KOBE UNIV,SCH MED,DEPT MICROBIOL,CHUO KU,7-5-1 KUSUNOKI CHO KOBE HYOGO 6500017 JAPAN KOBE UNIV,SCH MED,DEPT MICROBIOL,CHUO KU KOBE HYOGO 6500017 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 438, anno: 1998,
pagine: 258 - 262
SICI:
0014-5793(1998)438:3<258:COTNPO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-TERMINAL DOMAIN; NS3 PROTEIN; TRANSCRIPTIONAL ACTIVATION; HEPATOCELLULAR-CARCINOMA; CRYSTAL-STRUCTURE; HELICASE ACTIVITY; RNA-POLYMERASE; NS4A COFACTOR; CELLS;
Keywords:
HEPATITIS C VIRUS; NONSTRUCTURAL PROTEIN 3; P53 TUMOR SUPPRESSOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
S. Ishido e H. Hotta, "COMPLEX-FORMATION OF THE NONSTRUCTURAL PROTEIN-3 OF HEPATITIS-C VIRUSWITH THE P53 TUMOR-SUPPRESSOR", FEBS letters, 438(3), 1998, pp. 258-262

Abstract

By co-immunoprecipitation analysis, we demonstrated that wt-p53 formed a complex with non-structural protein (NS) 3 of hepatitis C virus, both in the absence and the presence of NS4A, a viral cofactor that strongly associates with NS3. Deletional analysis revealed that a portionnear the N-terminus of NS3 (amino acids (aa) 1055 and 1200), which isdifferent from the NS4A binding site, was necessary for the complex formation with wt-p53. On the other hand, a portion near the C-terminusof wt-p53 (aa 301-360), which has been reported to contain the oligomerization domain, was important for the complex formation with NS3. (C) 1998 Federation of European Biochemical Societies.

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Documento generato il 05/04/20 alle ore 03:36:33