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Titolo:
GENOTYPING OF HUMAN CYTOCHROME-P450 2A6 (CYP2A6), A NICOTINE C-OXIDASE
Autore:
OSCARSON M; GULLSTEN H; RAUTIO A; BERNAL ML; SINUES B; DAHL ML; STENGARD JH; PELKONEN O; RAUNIO H; INGELMANSUNDBERG M;
Indirizzi:
KAROLINSKA INST,INST ENVIRONM MED,DIV MOL TOXICOL,BOX 210 S-17177 STOCKHOLM SWEDEN KAROLINSKA INST,INST ENVIRONM MED,DIV MOL TOXICOL S-17177 STOCKHOLM SWEDEN OULU UNIV,DEPT PHARMACOL & TOXICOL FIN-90220 OULU FINLAND UNIV ZARAGOZA,DEPT PHARMACOL & PHYSIOL ES-5009 ZARAGOZA SPAIN HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT MED LAB SCI & TECHNOL,DIV CLIN PHARMACOL S-14186 HUDDINGE SWEDEN NATL PUBL HLTH INST,DEPT EPIDEMIOL & HLTH PROMOT FIN-00300 HELSINKI FINLAND
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 438, anno: 1998,
pagine: 201 - 205
SICI:
0014-5793(1998)438:3<201:GOHC2(>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LIVER-MICROSOMES; COUMARIN 7-HYDROXYLATION; METABOLIC-ACTIVATION; INTERINDIVIDUAL VARIABILITY; GENE; 2E1; POLYMORPHISM; POPULATION; OXIDATION; SUBSTRATE;
Keywords:
CYTOCHROME P450; COUMARIN; ALLELE; GENOTYPE; PHENOTYPE; METHOXYFLURANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Oscarson et al., "GENOTYPING OF HUMAN CYTOCHROME-P450 2A6 (CYP2A6), A NICOTINE C-OXIDASE", FEBS letters, 438(3), 1998, pp. 201-205

Abstract

Cytochrome P450 2A6 (CYP2A6) is a polymorphic enzyme responsible for the oxidation of certain precarcinogens and drugs and is the major nicotine C-oxidase, The role of CYP2A6 for nicotine elimination was emphasised recently by the finding that smokers carrying defective CYP2A6 alleles consumed fewer cigarettes [Pianezza et al, (1998) Nature 393, 750]. The method used for CYP2A6 genotyping has, however, been found togive erroneous results with respect to the coumarin hydroxylase phenotype, a probe reaction for the CYP2A6 enzyme. The present study describes an allele-specific PCR genotyping method that identifies the majordefective CYP2A6 allele and accurately predicts the phenotype, An allele frequency of 1-3% was observed in Finnish, Spanish, and Swedish populations, much lower than described previously. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:19:34