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Titolo:
EVIDENCE FOR INVOLVEMENT OF THE MELANOCORTIN MC4 RECEPTOR IN THE EFFECTS OF LEPTIN ON FOOD-INTAKE AND BODY-WEIGHT
Autore:
KASK A; RAGO L; WIKBERG JES; SCHIOTH HB;
Indirizzi:
TARTU STATE UNIV,DEPT PHARMACOL,ULIKOOLI 18 EE-50090 TARTU ESTONIA UPPSALA UNIV,DEPT PHARMACEUT PHARMACOL,BMC S-75124 UPPSALA SWEDEN
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 360, anno: 1998,
pagine: 15 - 19
SICI:
0014-2999(1998)360:1<15:EFIOTM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESITY; NEURONS; HYPOTHALAMUS; EXPRESSION; HORMONE; PROTEIN; GENE; MICE;
Keywords:
LEPTIN; MELANOCORTIN MC4; RECEPTOR; HS014; FOOD INTAKE; HYPERPHAGIA; BODY WEIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Kask et al., "EVIDENCE FOR INVOLVEMENT OF THE MELANOCORTIN MC4 RECEPTOR IN THE EFFECTS OF LEPTIN ON FOOD-INTAKE AND BODY-WEIGHT", European journal of pharmacology, 360(1), 1998, pp. 15-19

Abstract

The hypothesis that the melanocortin MC4 receptor mediates the homeostatic effects of leptin was tested. Leptin (0.3 nmol, i.c.v.) lowered food intake at 4 and 24 h and body weight at 24 h. This effect was inhibited by pretreatment with an analogue of melanocyte stimulating hormone (MSH), the selective melanocortin MC4 receptor antagonist HS014 (cyclic ys(11),D-Nal(14),Cys(18),Asp-NH222]-beta-MSH11-22, 0.3 nmol, i.c.v.). HS014 alone at this dose did not modify food intake or body weight. At a higher dose (1.0 nmol, i.c.v. ) HS014 stimulated food intake and this orexigenic effect of HS014 was attenuated by leptin pretreatment (0.3 nmol, i.c.v.). These results confirm earlier findings that leptin inhibits food intake and lowers body weight via the melanocortin system and suggest that leptin affects signalling at the melanocortin MC4 receptor. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:44:23