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Titolo:
EXTENSIVE VASCULOGENESIS, ANGIOGENESIS, AND ORGANOGENESIS PRECEDE LETHALITY IN MICE LACKING ALL ALPHA-V INTEGRINS
Autore:
BADER BL; RAYBURN H; CROWLEY D; HYNES RO;
Indirizzi:
MIT,HOWARD HUGHES MED INST,CTR CANC RES CAMBRIDGE MA 02139 MIT,HOWARD HUGHES MED INST,CTR CANC RES CAMBRIDGE MA 02139 MIT,DEPT BIOL CAMBRIDGE MA 02139
Titolo Testata:
Cell (Cambridge)
fascicolo: 4, volume: 95, anno: 1998,
pagine: 507 - 519
SICI:
0092-8674(1998)95:4<507:EVAAOP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; CELL-ADHESION; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; VASCULAR DEVELOPMENT; MESODERMAL DEFECTS; TARGETED MUTATIONS; DEFICIENT MICE; BLOOD-VESSELS; ALPHA(V)BETA(3);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Bader et al., "EXTENSIVE VASCULOGENESIS, ANGIOGENESIS, AND ORGANOGENESIS PRECEDE LETHALITY IN MICE LACKING ALL ALPHA-V INTEGRINS", Cell (Cambridge), 95(4), 1998, pp. 507-519

Abstract

alpha v integrins have been implicated in many developmental processes and are therapeutic targets for inhibition of angiogenesis and osteoporosis. Surprisingly, ablation of the gene for the alpha v integrin subunit, eliminating all five alpha v integrins, although causing lethality, allows considerable development and organogenesis including, most notably, extensive vasculogenesis and angiogenesis. Eighty percent of embryos die in midgestation, probably because of placental defects, but all embryos develop normally to E9.5, and 20% are born alive. These liveborn alpha v-null mice consistently exhibit intracerebral and intestinal hemorrhages and cleft palates. These results necessitate reevaluation of the primacy of alpha v integrins in many functions including vascular development, despite reports that blockade of these integrins with antibodies or peptides prevents angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:40:34