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Titolo:
MORPHOLOGICAL ABNORMALITIES OF ADRENAL-GLAND AND HYPERTROPHY OF LIVERIN MUTANT MICE LACKING RYANODINE RECEPTORS
Autore:
KOMAZAKI S; IKEMOTO T; TAKESHIMA H; IINO M; ENDO M; NAKAMURA H;
Indirizzi:
SAITAMA MED SCH,DEPT ANAT MOROYAMA SAITAMA 35004 JAPAN SAITAMA MED SCH,DEPT PHARMACOL MOROYAMA SAITAMA 35004 JAPAN UNIV TOKYO,FAC MED,DEPT PHARMACOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Cell and tissue research
fascicolo: 3, volume: 294, anno: 1998,
pagine: 467 - 473
SICI:
0302-766X(1998)294:3<467:MAOAAH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA2+ RELEASE CHANNELS; INOSITOL TRISPHOSPHATE; SKELETAL-MUSCLE; BRAIN; RAT;
Keywords:
RYANODINE RECEPTOR; HYPERTROPHY OF LIVER; ADRENAL ABNORMALITIES; KNOCKOUT MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S. Komazaki et al., "MORPHOLOGICAL ABNORMALITIES OF ADRENAL-GLAND AND HYPERTROPHY OF LIVERIN MUTANT MICE LACKING RYANODINE RECEPTORS", Cell and tissue research, 294(3), 1998, pp. 467-473

Abstract

Ryanodine receptors (RyRs), which form Ca2+ channels in the membrane of the endoplasmic reticulum, consist of three subtypes (RyR1, RyR2, and RyR3). The RyRs release Ca2+ from the endoplasmic reticulum into the cytoplasm and thus play an important role, especially in the contraction of skeletal and cardiac muscle cells. The genes of these RyRs arealso expressed in many non-muscle tissues, but the role played by RyRs in non-muscle cells is not fully understood. In the present study, we examined the morphological changes in such cells caused by a deficiency of RyRs genes using three mutant mice lacking RyR1, RyR3, or both RyR1 and RyR3. The results showed morphological abnormalities in the adrenal cortical cells in all three mutant mice. In addition, an excessive accumulation of glycogen granules in hepatic cells, and a hypertrophy of the liver were both present in those mutant mice lacking both RyR1 and RyR3. We discuss the relationship between the morphological abnormalities of the adrenal cortex and liver induced by a deficiency ofRyRs, and the possible causes of these abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:05:50