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Titolo:
THE FUCOSYLATION INDEX OF ALPHA-FETOPROTEIN AS A POSSIBLE PROGNOSTIC INDICATOR FOR PATIENTS WITH HEPATOCELLULAR-CARCINOMA
Autore:
AOYAGI Y; ISOKAWA O; SUDA T; WATANABE M; SUZUKI Y; ASAKURA H;
Indirizzi:
NIIGATA UNIV,SCH MED,DEPT INTERNAL MED,DIV 3,757 ASAHIMACHI DORI-1-BANCHO NIIGATA 9518122 JAPAN
Titolo Testata:
Cancer
fascicolo: 10, volume: 83, anno: 1998,
pagine: 2076 - 2082
SICI:
0008-543X(1998)83:10<2076:TFIOAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LENS-CULINARIS AGGLUTININ; LECTIN AFFINITY ELECTROPHORESIS; NEOPLASTIC DISEASES; EARLY DIAGNOSIS; SERUM; LIVER; PROFILES; CANCERS;
Keywords:
ALPHA-FETOPROTEIN; FUCOSYLATION INDEX; HEPATOCELLULAR CARCINOMA; PROGNOSTIC FACTOR; SURVIVAL RATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
Y. Aoyagi et al., "THE FUCOSYLATION INDEX OF ALPHA-FETOPROTEIN AS A POSSIBLE PROGNOSTIC INDICATOR FOR PATIENTS WITH HEPATOCELLULAR-CARCINOMA", Cancer, 83(10), 1998, pp. 2076-2082

Abstract

BACKGROUND. The aim of this study was to elucidate the usefulness of measuring the fucosylation index (FI) of or-fetoprotein (AFP) before the initiation of therapy as a new prognostic indicator for patients with hepatocellular carcinoma (HCC). METHODS. One hundred twelve patients with HCC who underwent transcatheter arterial embolization, chemoembolization, and/or percutaneous ethanol injection were examined in the current study. FI was determined by crossed immunoaffino-electrophoresis in the presence of Lens culinaris agglutinin. RESULTS. When the tentative discriminating value of FI was set at 18%, the mean survival rate for the group whose FI was higher than 18% was significantly lower than that for the group whose pi was equal to or less than 18%, according to the generalized Wilcoxon test (P = 0.0117) and the log rank test (P = 0.0183). The survival rate for HCC patients with AFP concentrations of more than 200 ng/mL was also significantly lower than that forpatients with AFP in the range of 21-200 ng/mL, according to the generalized Wilcoxon test (P = 0.0017) and the log rank test (P = 0.0018). When FI was combined with AFP concentration, a highly significant difference was observed between the group with FI > 18% and AFP > 200 ng/mL and another group with FI less than or equal to 18% and AFP less than or equal to 200 ng/mL, as determined by the generalized Wilcoxon test (P < 0.0001) and the log rank test (P = 0.0003). An analysis of multiple covariates in the prognostic factors with the Cox proportional hazards model showed that FI was one of the independent prognostic factors. CONCLUSIONS. The current study indicates that measuring FI from sera before the initiation of treatment serves as a new prognostic factor and may improve prognostic estimates and appraisal of therapeutic outcomes for patients with HCC. Cancer 1998;83:2076-82. (C) 1998 American Cancer Society.

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Documento generato il 26/09/20 alle ore 23:40:26