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Titolo:
C-MYB DOWN-REGULATION IS ASSOCIATED WITH HUMAN COLON CELL-DIFFERENTIATION, APOPTOSIS, AND DECREASED BCL-2 EXPRESSION
Autore:
THOMPSON MA; ROSENTHAL MA; ELLIS SL; FRIEND AJ; ZORBAS MI; WHITEHEAD RH; RAMSAY RG;
Indirizzi:
PETER MACCALLUM CANC INST,LOCKED BAG 1,ABECKETT ST MELBOURNE VIC 8006AUSTRALIA PETER MACCALLUM CANC INST MELBOURNE VIC 3002 AUSTRALIA PO ROYAL MELBOURNE HOSP,LUDWIG INST CANC RES MELBOURNE VIC 3050 AUSTRALIA
Titolo Testata:
Cancer research
fascicolo: 22, volume: 58, anno: 1998,
pagine: 5168 - 5175
SICI:
0008-5472(1998)58:22<5168:CDIAWH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN FATTY-ACIDS; SODIUM-BUTYRATE; ALKALINE-PHOSPHATASE; ANTISENSE OLIGODEOXYNUCLEOTIDES; COLORECTAL-CANCER; OVER-EXPRESSION; V-MYB; CARCINOMA; LINES; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Thompson et al., "C-MYB DOWN-REGULATION IS ASSOCIATED WITH HUMAN COLON CELL-DIFFERENTIATION, APOPTOSIS, AND DECREASED BCL-2 EXPRESSION", Cancer research, 58(22), 1998, pp. 5168-5175

Abstract

c-myb is expressed in human and murine colonic mucosa and elevated expression occurs in premalignant adenomatous polyps and carcinomas, c-Myb is required for colon cell proliferation, and there is evidence of c-myb down-regulation during differentiation. Recently, c-myb has beenimplicated in hematopoietic cell survival via regulation of bcl-2 gene expression. However, C-myb expression during terminal differentiation and apoptosis in the colonic crypt has not been examined. The experiments in this study examine the spatial and temporal expression of c-Myb protein in vivo using human colonic crypt sections and in vitro in human colon tumor cell Lines undergoing butyrate-induced differentiation and apoptosis. Electron microscopy, together with molecular and biochemical analysis, was used to define the differentiation status of the cells. Results demonstrate a decrease in c-Myb expression during thecommitment of cells to differentiation and apoptosis, Decreased levels of c-Myb are accompanied by a decrease in Bcl-2, These data suggest that the transcription factor c-Myb has a role in regulating the balance between proliferation, differentiation, and apoptosis in the colonic crypt. Furthermore, elevated c-Myb levels in colon tumor cells may lead to persistent bcl-2 expression, thus protecting tumor cells from programmed cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:12:24