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Titolo:
CELL-CELL INTERACTIONS DURING TRANSENDOTHELIAL MIGRATION OF TUMOR-CELLS
Autore:
VOURA EB; SANDIG M; SIU CH;
Indirizzi:
UNIV TORONTO,CHARLES H BEST INST,BANTING & BEST DEPT MED RES,112 COLLST TORONTO ON M5G 1L6 CANADA UNIV TORONTO,CHARLES H BEST INST,BANTING & BEST DEPT MED RES TORONTO ON M5G 1L6 CANADA UNIV TORONTO,DEPT BIOCHEM TORONTO ON M5G 1L6 CANADA
Titolo Testata:
Microscopy research and technique
fascicolo: 3, volume: 43, anno: 1998,
pagine: 265 - 275
SICI:
1059-910X(1998)43:3<265:CIDTMO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULE L1; HUMAN ENDOTHELIAL-CELLS; MELANOMA-CELLS; VASCULAR ENDOTHELIUM; TIGHT JUNCTIONS; PECAM-1 CD31; CYTOSKELETAL REARRANGEMENT; ALPHA-V-BETA-3 INTEGRINS; EXPERIMENTAL METASTASES; EXTRACELLULAR-MATRIX;
Keywords:
CELL ADHESION MOLECULES; ENDOTHELIUM; MELANOMA CELLS; CADHERINS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
102
Recensione:
Indirizzi per estratti:
Citazione:
E.B. Voura et al., "CELL-CELL INTERACTIONS DURING TRANSENDOTHELIAL MIGRATION OF TUMOR-CELLS", Microscopy research and technique, 43(3), 1998, pp. 265-275

Abstract

A key event in cancer metastasis is the transendothelial migration oftumor cells. This process involves multiple adhesive interactions between tumor cells and the endothelium. After adhering to the surface ofendothelial cells, tumor cells must penetrate the endothelial junction, which contains high concentrations of the cell adhesion molecules VE-cadherin and PECAM-1. Studies using an in vitro model system, consisting of melanoma cells which are seeded onto a monolayer of endothelial cells cultured on Matrigel, have revealed reorganization of the cytoskeleton and dynamic changes in the cell shape of both tumor and endothelial cells. The initial stages of transmigration are characterized by numerous membrane blebs protruding from the basolateral surfaces of the melanoma cells. Contact regions also show an abundance of microfilaments arising from the underlying endothelial cells. These adhesive interactions lead to the redistribution of both VE-cadherin and PECAM-1and, consequently, a localized dissolution of the endothelial junction. The penetration of the endothelial junction is initiated by melanoma pseudopods. Despite the disappearance of VE-cadherin from the retracting endothelial junction, heterotypic contacts between the tumor celland its surrounding endothelial cells show a high concentration of pan-cadherin staining, suggesting that transmigration of melanoma cells might yet be facilitated by interactions with another member of the cadherin family. Upon adhesion to the Matrigel, melanoma cells begin to spread and invade the matrix material, while the endothelial cells extend processes over the melanoma cells to reform the monolayer. Interestingly, the leading margins of these endothelial processes contain a high concentration of N-cadherin. VE-cadherin and PECAM-1 reappear onlywhen the advancing endothelial processes meet to reform the endothelial junction. Together, these observations suggest that endothelial cells actively participate in the transmigration of tumor cells and specific cadherins are involved in different steps of this complex process. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:06:01