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Titolo:
HEMIDESMOSOMES AND THEIR UNIQUE TRANSMEMBRANE PROTEIN BP180
Autore:
HIRAKO Y; OWARIBE K;
Indirizzi:
NAGOYA UNIV,GRAD SCH HUMAN INFORMAT,UNIT BIOSYST,CHIKUSA KU NAGOYA AICHI 4648601 JAPAN NAGOYA UNIV,SCH SCI,DEPT MOL BIOL NAGOYA AICHI 4648601 JAPAN NATL INST BASIC BIOL OKAZAKI AICHI 444 JAPAN
Titolo Testata:
Microscopy research and technique
fascicolo: 3, volume: 43, anno: 1998,
pagine: 207 - 217
SICI:
1059-910X(1998)43:3<207:HATUTP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BULLOUS PEMPHIGOID ANTIGEN; JUNCTIONAL EPIDERMOLYSIS-BULLOSA; INTEGRIN BETA-4 SUBUNIT; BASEMENT-MEMBRANE ADHESION; CELL-ADHESION; ALPHA(6)BETA(4) INTEGRIN; ANCHORING FILAMENTS; STRUCTURAL-ANALYSIS; MUSCULAR-DYSTROPHY; CYTOPLASMIC DOMAIN;
Keywords:
BULLOUS PEMPHIGOID; TYPE XVII COLLAGEN; BPAG2; BASEMENT MEMBRANE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
101
Recensione:
Indirizzi per estratti:
Citazione:
Y. Hirako e K. Owaribe, "HEMIDESMOSOMES AND THEIR UNIQUE TRANSMEMBRANE PROTEIN BP180", Microscopy research and technique, 43(3), 1998, pp. 207-217

Abstract

Hemidesmosomes are adhesion complexes responsible for linking keratinintermediate filaments of stratified and complex epithelia to components of the extracellular matrix such as collagen fibrils. Over the past several years, it has become clear that there are at least five hemidesmosomal proteins, including HD1/plectin and BP230 as cytoplasmic plaque proteins and integrin alpha 6 beta 4 and BP180 as transmembrane proteins. Among them, BP180 is unique as a transmembrane protein because of its collagenous extracellular domain. Recent biochemical and ultrastructural analyses have revealed its molecular configuration and nature as a major component of anchoring filaments connecting hemidesmosomes to the basement membrane. These results indicate that BP180 is a new type of adhesion receptor. In addition to biochemical analyses of these hemidesmosomal proteins, recent studies on patients with inherited skin blistering diseases and on knockout mice have demonstrated roles in hemidesmosome formation and stabilization, as well as unexpected,novel functions. (C) 1998 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:38:29