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Titolo:
THALAMOCORTICAL CIRCUITS CAUSING REMOTE HYPOMETABOLISM DURING FOCAL INTERICTAL EPILEPSY
Autore:
BRUEHL C; WAGNER U; HUSTON JP; WITTE OW;
Indirizzi:
NEUROL CLIN,MOORENSTR 5 D-40225 DUSSELDORF GERMANY NEUROL CLIN D-40225 DUSSELDORF GERMANY UNIV DUSSELDORF,INST PHYSIOL PSYCHOL D-40225 DUSSELDORF GERMANY
Titolo Testata:
Epilepsy research
fascicolo: 3, volume: 32, anno: 1998,
pagine: 379 - 387
SICI:
0920-1211(1998)32:3<379:TCCRHD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; THALAMIC PROJECTIONS; GLUCOSE-UTILIZATION; MOTOR CORTEX; RAT; METABOLISM; SEIZURES; ORGANIZATION; SEPARATION; CELLS;
Keywords:
EPILEPSY; HYPOMETABOLISM; PENICILLIN; POSTERIOR NUCLEUS; THALAMIC LESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C. Bruehl et al., "THALAMOCORTICAL CIRCUITS CAUSING REMOTE HYPOMETABOLISM DURING FOCAL INTERICTAL EPILEPSY", Epilepsy research, 32(3), 1998, pp. 379-387

Abstract

The functional circuit causing depression of cerebral glucose metabolism in brain areas remote from an epileptic focus was investigated in experiments on the cortex of the rat. Epileptic activity was induced by direct epicortical application of Na-penicillin onto the motor cortical area Fr1/Fr2. The increased neuronal activity was associated with an increase of metabolism in the focal area and a decrease in somatosensory cortical areas. Metabolism was also massively increased in the thalamus, predominantly in the posterior nucleus. Stereotactic radiofrequency lesioning of this nucleus, 30 days prior to the induction of the epileptic focus, restricted the area with increase of metabolism to the upper cortical laminae, and abolished the cortical hypometabolism in the sensory cortex. It is suggested that the primary functional circuit affected by the acute epileptic focus in the present model consists of the motor cortex, the thalamic nucleus posterior and the somatosensory cortex. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 00:48:49