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Titolo:
INFLUENCE OF 2 DIFFERENT TYPES OF EXCIPIENT ON DRUG PERCOLATION-THRESHOLD
Autore:
SORIANO MC; CARABALLO I; MILLAN M; PINERO RT; MELGOZA LM; RABASCO AM;
Indirizzi:
UNIV SEVILLE,FAC PHARM,DEPT PHARMACEUT TECHNOL,C PROF GARCIA GONZALEZS-N E-41012 SEVILLE SPAIN
Titolo Testata:
International journal of pharmaceutics
fascicolo: 1-2, volume: 174, anno: 1998,
pagine: 63 - 69
SICI:
0378-5173(1998)174:1-2<63:IO2DTO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX TABLETS; SYSTEMS;
Keywords:
PERCOLATION THEORY; PERCOLATION THRESHOLD; INERT MATRICES; CONTROLLED RELEASE; ETHYL CELLULOSE; EUDRAGIT(R) RS-PM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Soriano et al., "INFLUENCE OF 2 DIFFERENT TYPES OF EXCIPIENT ON DRUG PERCOLATION-THRESHOLD", International journal of pharmaceutics, 174(1-2), 1998, pp. 63-69

Abstract

The application of the principles of percolation theory is providing a more rational pharmaceutical dosage form design. The drug percolation threshold is the parameter that provides a better description of thesystem according to this theory. In order to check the possibility ofuse the drug percolation threshold as a preformulation parameter, theinfluence of the main formulation factors is being studied. The aim of this work is to study the influence of the type of excipient on the drug percolation threshold. For this purpose, two excipients exhibiting Very different mechanical behaviour have been selected. Inert matrices were prepared using Ethocel(R) 100 and Eudragit(R) RS-PM as excipients and KCI as a model drug. Release assays were performed using the rotating disk method. The drug percolation threshold was estimated employing the method of Leuenberger and Bonny. The following confidence intervals (95%) were obtained: epsilon(c) = 0.3644 +/- 0.0641 and epsilon(c) = 0.3407 +/- 0.0345 of total porosity for matrices containing Eudragit(R) RS-PM and Ethocel(R) 100, respectively. On the light of the obtained results, no significant differences were found on the drug percolation thresholds for two excipients having very different mechanical behaviour. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:15:04