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Titolo:
SCREENING STRUCTURAL-FUNCTIONAL RELATIONSHIPS OF NEUROPHARMACOLOGICALLY ACTIVE ORGANIC-COMPOUNDS AT THE NICOTONIC ACETYLCHOLINE-RECEPTOR
Autore:
BARRANTES GE; ORTELLS MO; BARRANTES FJ;
Indirizzi:
INST INVEST BIOQUIM,CC 857 RA-8000 BAHIA BLANCA ARGENTINA INST INVEST BIOQUIM RA-8000 BAHIA BLANCA ARGENTINA
Titolo Testata:
Neuropharmacology
fascicolo: 3, volume: 36, anno: 1997,
pagine: 269 - 279
SICI:
0028-3908(1997)36:3<269:SSRON>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 MEPROADIFEN MUSTARD; ION-CHANNEL; NONCOMPETITIVE ANTAGONIST; NICOTINIC RECEPTOR; TORPEDO-MARMORATA; LOCAL-ANESTHETICS; BINDING-SITE; BLOCKADE; METHYLLYCACONITINE; PHYSOSTIGMINE;
Keywords:
MOLECULAR MODELING; DRUG SCREENING; NICOTINIC ACETYLCHOLINE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Barrantes et al., "SCREENING STRUCTURAL-FUNCTIONAL RELATIONSHIPS OF NEUROPHARMACOLOGICALLY ACTIVE ORGANIC-COMPOUNDS AT THE NICOTONIC ACETYLCHOLINE-RECEPTOR", Neuropharmacology, 36(3), 1997, pp. 269-279

Abstract

The mechanisms of action and pharmacological effects on the nicotiniccholinoceptor of a large database of organic compounds were analyzed using a new computational procedure. This procedure is a screening method based on comparison of the molecular structures (shape and charge)of the putative active organic compounds. The resulting predictions can be used as an exploratory tool in the design of experiments aimed at testing the effects of several compounds on a target macromolecule. Unlike a conventional database search for structural similarities, thepresent method is able to circumscribe objectively the results to themost statistically significant molecules. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:47:47