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Titolo:
ANALYSIS OF THE ANTIGENIC PROPERTIES OF THE L-INFANTUM HSP70 - DESIGNOF SYNTHETIC PEPTIDES FOR SPECIFIC SERODIAGNOSIS OF HUMAN LEISHMANIASIS
Autore:
QUIJADA L; REQUENA JM; SOTO M; ALONSO C;
Indirizzi:
UNIV AUTONOMA MADRID,CSIC,UAM,CTR BIOL MOL SEVERO OCHOA E-28049 MADRID SPAIN UNIV AUTONOMA MADRID,CSIC,UAM,CTR BIOL MOL SEVERO OCHOA E-28049 MADRID SPAIN
Titolo Testata:
Immunology letters
fascicolo: 3, volume: 63, anno: 1998,
pagine: 169 - 174
SICI:
0165-2478(1998)63:3<169:AOTAPO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACIDIC RIBOSOMAL-PROTEINS; HEAT-SHOCK PROTEIN; VISCERAL LEISHMANIASIS; CUTANEOUS LEISHMANIASIS; TRYPANOSOMA-CRUZI; IDENTIFICATION; DETERMINANTS; ANTIBODIES; RESPONSES; CHAGASI;
Keywords:
HSP70; B-CELL EPITOPE; SERODIAGNOSIS; LEISHMANIA INFANTUM; MUCOCUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
L. Quijada et al., "ANALYSIS OF THE ANTIGENIC PROPERTIES OF THE L-INFANTUM HSP70 - DESIGNOF SYNTHETIC PEPTIDES FOR SPECIFIC SERODIAGNOSIS OF HUMAN LEISHMANIASIS", Immunology letters, 63(3), 1998, pp. 169-174

Abstract

The 70-kDa heat shock protein (Hsp70) is a major target of the humoral immune response during Leishmania infections. In the present paper, it is shown that 84.6% of sera from mucocutaneous leishmaniasis (MCL) patients and 78.9% of sera from visceral leishmaniasis Oil) patients reacted with the L. infantum Hsp70. The mapping of the antigenic determinants indicated that this protein is highly rich in linear B-epitopes. As the complete protein cannot be used for specific serodiagnosis ofVL because it is also recognized by the sera from Chagas' disease patients, a search for specific epitopes recognized by leishmaniasis patients was undertaken. A 50-mer synthetic peptide, located in the most divergent region of the protein, was found to be recognized by a high percentage of leishmaniasis sera and not recognized by chagasic sera. Such a tool would be particularly useful for serodiagnosis of leishmaniasis in geographical areas where mixed infections with Trypanosoma cruzi and Leishmania occurs. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:19:16