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Titolo:
VITAMIN-E ADMINISTRATION IMPROVES IMPAIRMENT OF ENDOTHELIUM-DEPENDENTVASODILATION IN PATIENTS WITH CORONARY SPASTIC ANGINA
Autore:
MOTOYAMA T; KAWANO H; KUGIYAMA K; HIRASHIMA O; OHGUSHI M; TSUNODA R; MORIYAMA Y; MIYAO Y; YOSHIMURA M; OGAWA H; YASUE H;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DIV CARDIOL,HONJO 1-1-1 KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DIV CARDIOL KUMAMOTO 860 JAPAN
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 6, volume: 32, anno: 1998,
pagine: 1672 - 1679
SICI:
0735-1097(1998)32:6<1672:VAIIOE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKE EXTRACT; FREE-RADICAL INJURY; ARTERY SPASM; SUPEROXIDE ANION; RELAXING FACTOR; VARIANT ANGINA; HEART-DISEASE; RISK FACTOR; DYSFUNCTION; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
T. Motoyama et al., "VITAMIN-E ADMINISTRATION IMPROVES IMPAIRMENT OF ENDOTHELIUM-DEPENDENTVASODILATION IN PATIENTS WITH CORONARY SPASTIC ANGINA", Journal of the American College of Cardiology, 32(6), 1998, pp. 1672-1679

Abstract

Objectives. We examined the effects of oral administration of vitaminE, an antioxidant, on endothelium-dependent vasodilation in patients with coronary spastic angina. Background. We have recently reported that endothelium-dependent vasodilation is impaired in patients with coronary spastic angina (CSA). Furthermore, it is known that oxidative stress may play an important role in the impairment of endothelium dependent vasodilation in cardiovascular diseases. Methods. With the ultrasound technique, flow-dependent vasodilation of the brachial arteries during reactive hyperemia was exam ined before and after treatment for a month with either oral administration of vitamin E (alpha-tocopherolacetate, 300 mg/day) or placebo, which is randomly assigned, in patients with CSA (n = 60). Results. Before treatment, patients with CSA had impaired flow dependent vasodilation, lower plasma levels of alpha-tocopherol and higher plasma levels of thiobarbituric acid reactive substances (TBARS), as compared with age- and sex-matched control subjects (n = 60) (flow-dependent vasodilation: 3.1 +/- 1.8 vs. 7.1 +/- 2.5%,p < 0.001; alpha-tocopherol levels: 8.9 +/- 1.8 vs. 10.8 +/- 1.8 mu g/ml, p < 0.001). In patients with CSA, treatment,vith vitamin E restored flow-dependent vasodilation (3.1 +/- 1.7 vs. 8.3 +/- 2.0%, p < 0.001), and this improvement was associated with the decreases in plasma TBARS levels and anginal attacks. Conclusions. The results indicate that vitamin E treatment improved endothelium dependent vasodilation and decreased plasma TBARS levels in patients with CSA. Thus, increased oxidative stress may contribute to endothelial dysfunction and anginal attacks in patients with CSA. (J Am Coll Cardiol 1998;32:1672-9) (C)1998 by the American College of Cardiology.

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Documento generato il 30/11/20 alle ore 07:09:19