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Titolo:
LONG-TERM ADMINISTRATION OF G-CSF FOR APLASTIC-ANEMIA IS CLOSELY-RELATED TO THE EARLY EVOLUTION OF MONOSOMY-7 MDS IN ADULTS
Autore:
KAITO K; KOBAYASHI M; KATAYAMA T; MASUOKA H; SHIMADA T; NISHIWAKI K; SEKITA T; OTSUBO H; OGASAWARA Y; HOSOYA T;
Indirizzi:
JIKEI UNIV,SCH MED,DEPT INTERNAL MED 2,MINATO KU,3-19-18 NISHI SHINBASHI TOKYO 1058461 JAPAN JIKEI UNIV,SCH MED,KASHIWA HOSP,DEPT GEN INTERNAL MED TOKYO 1058461 JAPAN
Titolo Testata:
British Journal of Haematology
fascicolo: 2, volume: 103, anno: 1998,
pagine: 297 - 303
SICI:
0007-1048(1998)103:2<297:LAOGFA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; BONE-MARROW TRANSPLANTATION; ANTITHYMOCYTE GLOBULIN; MYELODYSPLASTIC SYNDROME; ANTILYMPHOCYTE GLOBULIN; MYELOID DISORDERS; ANEMIA; CYCLOSPORINE; LEUKEMIA;
Keywords:
APLASTIC ANEMIA; MONOSOMY 7; MDS; G-CSF; CYCLOSPORINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
K. Kaito et al., "LONG-TERM ADMINISTRATION OF G-CSF FOR APLASTIC-ANEMIA IS CLOSELY-RELATED TO THE EARLY EVOLUTION OF MONOSOMY-7 MDS IN ADULTS", British Journal of Haematology, 103(2), 1998, pp. 297-303

Abstract

There is an increasing incidence of the evolution of myelodysplastic syndrome (MDS) from aplastic anaemia (AA) with immunosuppressive treatment. In paediatric patients G-CSF is also reported to increase MDS evolution, but this process is not precisely understood in children or in adults. Therefore risk factors of MDS evolution in adults are evaluated here. Of 72 patients, five developed MDS. In 47 patients without cyclosporine (CyA) or antithymocyte globulin (ATG) therapy, only one developed MDS with trisomy 8, 242 months after diagnosis. But of 25 patients treated with either CyA or ATG, four developed monosomy 7 MDS within 3 pears, Of these 25 patients, 18 were treated with G-CSF and the four patients (22.2%) who developed MDS were found in this group. The cumulative dose and the duration of G-CSF administration were significantly elevated in patients who developed MDS when compared with those who did not, 822.3 +/- 185.0 v 205.4 +/- 25.5 mu g/kg (P < 0.05) and 187.5 +/- 52.5 v 72.0 +/- 24.6 d (P < 0.002), respectively. However these two values for CyA did not differ significantly. Statistically treatment with CyA, G-CSF and combined G-CSF and CyA were significantly related to MDS evolution. The administration of G-CSF for more than a year was the most important factor (P = 0.00). These results suggested that a close relationship exists between G-CSF and subsequent monosomy 7 MDS from AA in adults who receive immunosuppressive therapy. Long-term administration of G-CSF should be prohibited in order to prevent MDS evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:02:05