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Titolo:
HIGHLY-ACTIVE ANTIRETROVIRAL THERAPY NORMALIZES THE FUNCTION OF PROGENITOR CELLS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS
Autore:
NIELSEN SD; ERSBOLL AK; MATHIESEN L; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB,144,2650 HVIDOVRE DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB DK-2650 HVIDOVRE DENMARK ROYAL VET & AGR UNIV,DEPT ANIM SCI & ANIM HLTH DK-1870 FREDERIKSBERG DENMARK
Titolo Testata:
The Journal of infectious diseases
fascicolo: 5, volume: 178, anno: 1998,
pagine: 1299 - 1305
SICI:
0022-1899(1998)178:5<1299:HATNTF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW CELLS; HEMATOPOIETIC PROGENITORS; T-CELL; IN-VITRO; CD34+ CELLS; MYELOID DIFFERENTIATION; ENVELOPE GLYCOPROTEIN; PERIPHERAL-BLOOD; MAJOR RESERVOIR; HIV-INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S.D. Nielsen et al., "HIGHLY-ACTIVE ANTIRETROVIRAL THERAPY NORMALIZES THE FUNCTION OF PROGENITOR CELLS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS", The Journal of infectious diseases, 178(5), 1998, pp. 1299-1305

Abstract

CD34 cells from human immunodeficiency virus (HIV)-infected persons have been described to be impaired in function. The effect of highly active antiretroviral treatment (HAART) on the function of CD34 cells inHIV-infected patients was examined. Numbers and function of CD34 cells from 11 HIV-infected patients were determined prior to HAART and after 2, 4, 8, and 12 weeks of therapy The mean number of colony-forming units (cells) per milliliter (cfu/mL) was 15.0 prior to HAART vs. 109.8 in healthy controls (P < .001). During HAART, the number of cfu/mL increased to 100.3 (P < .001). This increase in cfu/mL eliminated the differences between HN-infected patients and controls. Significant increases in numbers of CD34 cells were not detected. Of importance, the cloning efficiency of CD34 cells increased from 1.7% prior to therapy to a peak at 18.7% (P = .003), In conclusion, HAART normalized CD34 cell function in HIV-infected patients and thus might allow de novo production of T lymphocytes from progenitor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:12:50