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Titolo:
DURATION OF DIABETES AND CAROTID WALL THICKNESS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY (IRAS)
Autore:
WAGENKNECHT LE; DAGOSTINO R; SAVAGE PJ; OLEARY DH; SAAD MF; HAFFNER SM;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT MICROBIOL & PUBL HLTH,MED CTR BLVD WINSTON SALEM NC 27157 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,NIH BETHESDA MD 20892 TUFTS UNIV NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 02111 UNIV SO CALIF,MED CTR,DEPT MED LOS ANGELES CA 00000 UNIV TEXAS,HLTH SCI CTR,DEPT MED SAN ANTONIO TX 78284
Titolo Testata:
Stroke
fascicolo: 5, volume: 28, anno: 1997,
pagine: 999 - 1005
SICI:
0039-2499(1997)28:5<999:DODACW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; GLYCOSYLATION END-PRODUCTS; B-MODE ULTRASOUND; ARTERIAL-WALL; MEDIAL THICKNESS; MELLITUS; COMPLICATIONS; ASSOCIATION; MORTALITY;
Keywords:
ATHEROSCLEROSIS; CAROTID ARTERIES; DIABETES MELLITUS; HYPERGLYCEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Wagenknecht et al., "DURATION OF DIABETES AND CAROTID WALL THICKNESS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY (IRAS)", Stroke, 28(5), 1997, pp. 999-1005

Abstract

Background and Purpose Diabetes is a major risk factor for morbidity and mortality from cardiovascular disease. However, the role of the primary metabolic abnormality of diabetes (chronic hyperglycemia) in this disease process has not been fully elucidated. Methods A cross-sectional analysis was conducted among 489 persons with non-insulin-dependent diabetes mellitus; 299 were established diabetics (diagnosed previously) and 190 were newly diagnosed at the time of the Insulin Resistance Atherosclerosis Study (IRAS) examination. These men and women, of three different ethnic groups, were participants in IRAS. Established diabetes (versus newly diagnosed diabetes) and mean fasting glucose level were used as measures of hyperglycemic burden. Intimal-medial wall thickness (IMT) of the internal (ICA) and common (CCA) carotid arteries were used as indices of atherosclerosis. Results The mean duration of disease among established diabetics was 7 years. The mean CCA IMT and ICA IMT were 872 and 946 mu m, respectively. Established diabetes and mean fasting glucose level were positively associated with increasedCCA IMT (P<.05) but not ICA IMT, even after adjustment for numerous cardiovascular disease risk factors. CCA IMT was increased by 70 mu m in established diabetics (versus newly diagnosed diabetics) and by 26 mu m per 1 SD of fasting glucose. Among established diabetics, however,duration of known diabetes (number of years) was not significantly related to IMT. Conclusions Among diabetics in IRAS, established diabetes and fasting glucose level were each independently associated with CCA IMT, suggesting that chronic hyperglycemia or its associated metabolic abnormalities may lead to increased risk of atherosclerosis.

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Documento generato il 27/11/20 alle ore 04:40:16