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Titolo:
HEMORRHAGIC TRANSFORMATION IN ACUTE ISCHEMIC STROKE - POTENTIAL CONTRIBUTING FACTORS IN THE EUROPEAN COOPERATIVE ACUTE STROKE STUDY
Autore:
LARRUE V; VONKUMMER R; DELZOPPO G; BLUHMKI E;
Indirizzi:
UNIV TOULOUSE,NEUROL SERV,HOP RANGUEIL,DEPT NEUROL F-31403 TOULOUSE 04 FRANCE UNIV DRESDEN,DEPT NEURORADIOL DRESDEN GERMANY SCRIPPS CLIN & RES INST,DEPT MOL & EXPT MED LA JOLLA CA 00000 DR KARL THOMAE GMBH D-7950 BIBERACH GERMANY BOEHRINGER INGELHEIM BIBERACH GERMANY
Titolo Testata:
Stroke
fascicolo: 5, volume: 28, anno: 1997,
pagine: 957 - 960
SICI:
0039-2499(1997)28:5<957:HTIAIS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; MIDDLE CEREBRAL-ARTERY; INFARCTION; THROMBOLYSIS; THERAPY; TRIAL; TIME; RISK; CT;
Keywords:
CEREBRAL HEMORRHAGE; RISK FACTORS; STROKE, ACUTE; THROMBOLYTIC THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
V. Larrue et al., "HEMORRHAGIC TRANSFORMATION IN ACUTE ISCHEMIC STROKE - POTENTIAL CONTRIBUTING FACTORS IN THE EUROPEAN COOPERATIVE ACUTE STROKE STUDY", Stroke, 28(5), 1997, pp. 957-960

Abstract

Background and Purpose Recent studies suggest that thrombolytic therapy may be of benefit to patients with acute ischemic stroke. However, the treatment also carries a significant risk of hemorrhagic transformation (HT). The purpose of this study was to select potential contributors to HT. Methods We provide an explanatory analysis of the EuropeanCooperative Acute Stroke Study (ECASS) data. ECASS was a multicenter,placebo-controlled, randomized trial of recombinant tissue plasminogen activator in ischemic stroke, within 6 hours of symptom onset, whichenrolled 620 patients. HTs were classified into either hemorrhagic infarction or parenchymal hemorrhage according to their CT scan appearance. We used logistic regression analysis to select potential contributing factors to each type of HT. Results The severity of initial clinical deficit (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.6 to4.0) and the presenceof early ischemic changes on CT scan (OR, 3:5; 95% CI. 2.3 to 5.3) were associated with increased risk of hemorrhagic infarction. Increasing age (in decades; OR, 1.3; 95% CI, 1.0 to 1.7) and treatment with recombinant tissue plasminogen activator (OR, 3.6; 95% CI, 2.1 to 6.1) were related to the risk of parenchymal hemorrhage. Conclusions Since all potential contributing factors are readily discernible upon hospital admission, they should be used to improve selection of patients into future studies.

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Documento generato il 28/11/20 alle ore 03:19:12