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Titolo:
LACTATE CANNOT SUBSTITUTE FOR ALANINE IN D4T-BASED ANTI-HIV NUCLEOTIDE PRODRUGS - DESPITE EFFICIENT ESTERASE-MEDIATED HYDROLYSIS
Autore:
MCGUIGAN C; CAHARD D; BALLATORE C; SIDDIQUI A; DECLERCQ E; BALZARINI J;
Indirizzi:
UNIV WALES COLL CARDIFF,WELSH SCH PHARM,KING EDWARD 7 AVE CARDIFF CF13XF S GLAM WALES KATHOLIEKE UNIV LEUVEN,REGA INST MED RES B-3000 LOUVAIN BELGIUM
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 21, volume: 8, anno: 1998,
pagine: 2949 - 2954
SICI:
0960-894X(1998)8:21<2949:LCSFAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHORAMIDATE DERIVATIVES; INTRACELLULAR DELIVERY; D4T; 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE; METABOLISM; EFFICACY; POTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
C. Mcguigan et al., "LACTATE CANNOT SUBSTITUTE FOR ALANINE IN D4T-BASED ANTI-HIV NUCLEOTIDE PRODRUGS - DESPITE EFFICIENT ESTERASE-MEDIATED HYDROLYSIS", Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 2949-2954

Abstract

As part of our on-going effort to deliver masked phosphates of antiviral nucleosides inside living cells we have previously discovered thatamino acid-derived phosphoramidates are particularly effective. Here we report that lactate analogues, with a simple change of bridging nitrogen for oxygen, are virtually inactive as antiviral agents and apparently do not achieve intracellular nucleoside phosphate delivery. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:13:41