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Titolo:
ISOTHERMAL AND NONISOTHERMAL DECOMPOSITION OF THYMOPENTIN AND ITS ANALOGS IN AQUEOUS-SOLUTION
Autore:
LEE ML; STAVCHANSKY S;
Indirizzi:
UNIV TEXAS,DIV PHARMACEUT,COLL PHARM AUSTIN TX 78712 UNIV TEXAS,DIV PHARMACEUT,COLL PHARM AUSTIN TX 78712
Titolo Testata:
Pharmaceutical research
fascicolo: 11, volume: 15, anno: 1998,
pagine: 1702 - 1707
SICI:
0724-8741(1998)15:11<1702:IANDOT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC PENTAPEPTIDE; THYMOPOIETIN-II; STABILITY; KINETICS;
Keywords:
STABILITY; ISOTHERMAL; NONISOTHERMAL; THYMOPENTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Lee e S. Stavchansky, "ISOTHERMAL AND NONISOTHERMAL DECOMPOSITION OF THYMOPENTIN AND ITS ANALOGS IN AQUEOUS-SOLUTION", Pharmaceutical research, 15(11), 1998, pp. 1702-1707

Abstract

Purpose. The degradation kinetics of thymopentin (RKDVY) and its analogs (RKDVW and RPDVY) in aqueous solution was studied by isothermal and nonisothermal methods. Methods. The isothermal decomposition of thymopentin and its analogs was investigated as a function of pH (2-10), temperature (37, 57, and 80 degrees C) and ionic strength (mu = 0.02 to1). Nonisothermal decomposition studies were performed using a lineartemperature programmer. The temperature increasing rate was set to 0.25 degrees C per hour and the temperature interval varied from 40 to 88 degrees C. Results. The decomposition of thymopentin and its analogsfollowed first order kinetics. The dependence of the rate constant ontemperature followed a linear Arrhenius plot. This indicated that thedegradation mechanism of thymopentin and its analogs might be the same within the temperature range studied. The energies of activation were found to be in close agreement for the isothermal and nonisothermal studies, suggesting that the nonisothermal studies may save considerable amount of time in the early stages of drug development. The logK-pHprofile of thymopentin suggests that maximum stability is achieved inthe pH range of 6-8. Conclusions. These results indicate that the nonisothermal methodology provides an attractive alternative to isothermal methods, as it requires a much lower amount of both material and time, to determine the peptide stability and to estimate the shelf-life for peptide pharmaceutical preparations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:35:46