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Titolo:
IS THE PLACEBO CONTROL OBSOLETE IN A WORLD AFTER DONEPEZIL AND VITAMIN-E
Autore:
KARLAWISH JHT; WHITEHOUSE PJ;
Indirizzi:
INST AGING,DEPT MED,DIV GERIATR,3615 CHESTNUT ST PHILADELPHIA PA 19104 UNIV PENN,CTR BIOETH PHILADELPHIA PA 19104 UNIV HOSP CLEVELAND,CASE WESTERN RESERVE UNIV,DIV BEHAV & GERIATR NEUROL CLEVELAND OH 00000
Titolo Testata:
Archives of neurology
fascicolo: 11, volume: 55, anno: 1998,
pagine: 1420 - 1424
SICI:
0003-9942(1998)55:11<1420:ITPCOI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL RESEARCH; DEVELOPING-COUNTRIES; ALZHEIMERS-DISEASE; INFORMED CONSENT; TRIALS; EQUIPOISE; ETHICS; PROXY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.H.T. Karlawish e P.J. Whitehouse, "IS THE PLACEBO CONTROL OBSOLETE IN A WORLD AFTER DONEPEZIL AND VITAMIN-E", Archives of neurology, 55(11), 1998, pp. 1420-1424

Abstract

Recent clinical trials of donepezil and vitamin E have produced active therapeutic drugs for the treatment of patients with Alzheimer disease (AD). The AD research community is now in a gray zone between the absence of accepted therapies and the presence of completely effective therapies. How should these therapies guide the choice of the proper control for future AD clinical trials? The community equipoise principle can guide a process to answer this question. The principle is that aclinical trial should answer clinical questions that are valued by the community who will use the results of that trial. This means that the choice of the proper control for future AD clinical trials ought to be guided by the values of a community who will experience the resultsof those trials: physicians and patients or their representatives such as caregivers. The values of patients can be included by giving thema voice in the design and review of clinical trials. Community dialogue should be the norm for the design and review of AD clinical trials. We conclude with suggestions to foster this dialogue and issues that should be addressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:22:33