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Titolo:
EMBRYOLOGY AND ENDOCRINOLOGY OF GENITAL DEVELOPMENT
Autore:
REY R; PICARD JY;
Indirizzi:
HOSP NINOS DR RICARDO GUTIERREZ,CENT INVEST ENDOCRINOL,NATL SCI RES COUNCIL,CONICET,GALLO 1330 RA-1425 BUENOS AIRES DF ARGENTINA ECOLE NORMALE SUPER,DEPT BIOL,INSERM,UNITE RECH ENDOCRINOL DEV F-92120 MONTROUGE FRANCE
Titolo Testata:
Bailliere's clinical endocrinology and metabolism
fascicolo: 1, volume: 12, anno: 1998,
pagine: 17 - 33
SICI:
0950-351X(1998)12:1<17:EAEOGD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-MULLERIAN HORMONE; RECEPTOR STEROIDOGENIC FACTOR-1; INHIBITING SUBSTANCE GENE; DUCT SYNDROME; MOLECULAR-GENETICS; MALE PSEUDOHERMAPHRODITISM; TESTICULAR DESCENT; MISSENSE MUTATION; SEX DETERMINATION; II RECEPTOR;
Keywords:
SEXUAL DIFFERENTIATION; FETUS; EXTERNAL GENITALIA; INTERNAL GENITALIA; ANTIMULLERIAN HORMONE; ANDROGENS; TESTOSTERONE; MULLERIAN DUCTS; WOLFFIAN DUCTS; PERSISTENT MULLERIAN DUCT SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
R. Rey e J.Y. Picard, "EMBRYOLOGY AND ENDOCRINOLOGY OF GENITAL DEVELOPMENT", Bailliere's clinical endocrinology and metabolism, 12(1), 1998, pp. 17-33

Abstract

In the human male fetus, testes develop by the 7th week and begin to secrete two hormones: and-mullerian hormone (AMH) induces the regression of mullerian ducts, the anlagen of the uterus, fallopian tubes and upper vagina, upon binding to a specific membrane receptor, whereas testosterone induces the differentiation of the wolffian ducts into the epididymes, vasa deferentia and seminal vesicles. in some target tissues, testosterone is converted to dihydrotestosterone, which is responsible for masculinization of the urogenital sinus and external genitalia. Both androgens act upon binding to the same nuclear receptor. In the absence of AMH and androgen action, for example in the female or in abnormal male differentiation, the internal and external genital primordia differentiate following the female pathway, even in the absence of ovaries. In males, an impaired function of the AMH-dependent pathwayresults in the persistent mullerian duct syndrome, a disorder characterized by the presence of uterus and fallopian tubes in otherwise normally virilized boys. Several mutations found in the AMH and AMH-receptor genes explain the pathophysiology of this syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:20:43