Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LOW-LEVEL OF MIXING OF PARTNER CELLS SEEN IN EXTRATHYMIC T-CELLS IN THE LIVER AND INTESTINE OF PARABIOTIC MICE - ITS BIOLOGICAL IMPLICATION
Autore:
SUZUKI S; SUGAHARA S; SHIMIZU T; TADA T; MINAGAWA M; MARUYAMA S; WATANABE H; SAITO H; ISHIKAWA H; HATAKEYAMA K; ABO T;
Indirizzi:
NIIGATA UNIV,SCH MED,DEPT IMMUNOL NIIGATA 9518510 JAPAN NIIGATA UNIV,SCH MED,DEPT IMMUNOL NIIGATA 9518510 JAPAN NIIGATA UNIV,SCH MED,DEPT SURG 1 NIIGATA 9518510 JAPAN KEIO UNIV,SCH MED,DEPT MICROBIOL TOKYO 160 JAPAN
Titolo Testata:
European Journal of Immunology
fascicolo: 11, volume: 28, anno: 1998,
pagine: 3719 - 3729
SICI:
0014-2980(1998)28:11<3719:LOMOPC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW; THYMOCYTE-PRECURSORS; SUPPRESSOR MACROPHAGES; BLOOD MONOCYTES; IMMUNE ORGANS; KUPFFER CELLS; STEM-CELLS; RECEPTOR; THYMUS; LYMPHOCYTES;
Keywords:
C-KIT(+) STEM CELL; EXTRATHYMIC T CELL; NK T CELL; PARABIOSIS; DIGESTIVE TRACT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S. Suzuki et al., "LOW-LEVEL OF MIXING OF PARTNER CELLS SEEN IN EXTRATHYMIC T-CELLS IN THE LIVER AND INTESTINE OF PARABIOTIC MICE - ITS BIOLOGICAL IMPLICATION", European Journal of Immunology, 28(11), 1998, pp. 3719-3729

Abstract

c-kit(+) stem cells have recently been found in the liver and intestine of adult mice. We examined whether such stem cells give rise to extrathymic T cells in these organs in situ. To this end, we used parabiotic B6.Ly5.1 and B6.Ly5.2 mice, i.e. mice sharing the circulation. Theorigin of lymphocytes was identified by anti-Ly5.1 and anti-Ly5.2 monoclonal antibodies in conjunction with immunofluorescence assays. Lymphocytes in the blood, spleen, lymph nodes and liver had become a half-and-half mixture of Ly5.1(+) and Ly5.2(+) cells in both individuals byday 14. However, this level of mixing decreased in extrathymic T cells in the liver (i.e. NK T cells) and intestine by day 14 and thereafter. The same was observed in T cells of the thymus. The data from immunohistochemical staining supported the results of immunofluorescence assays for suspension cells. The present results raise the possibility that extrathymic T cells in the liver and intestine may arise from their own pre-existing precursor cells, possibly from their own stem cells. Another important finding was that the composition pattern of lymphocyte subsets in one individual was quite similar to that in its partner at various sites. This result was interpreted to mean that only selected partner cells migrate to specific sites in the other partner individual.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:52:26