Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CD38(-CELLS - A POPULATION OF T-CELLS WITH IMMUNE REGULATORY ACTIVITIES IN-VITRO() CD45RB(LOW) CD4(+) T)
Autore:
READ S; MAUZE S; ASSEMAN C; BEAN A; COFFMAN R; POWRIE F;
Indirizzi:
UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG OXFORD OX3 9DU ENGLAND UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG OXFORD OX3 9DU ENGLAND DNAX RES INST MOL & CELLULAR BIOL INC,DEPT IMMUNOBIOL PALO ALTO CA 94304
Titolo Testata:
European Journal of Immunology
fascicolo: 11, volume: 28, anno: 1998,
pagine: 3435 - 3447
SICI:
0014-2980(1998)28:11<3435:C-APOT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAPHYLOCOCCAL-ENTEROTOXIN-B; LYMPHOCYTE-T; PERIPHERAL TOLERANCE; MONOCLONAL-ANTIBODY; DISTINCT SUBSETS; CLONAL ANERGY; IN-VITRO; ANTIGEN; EXPRESSION; ACTIVATION;
Keywords:
CD4(+) T CELL SUBSET; IMMUNE REGULATION; REGULATORY T CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S. Read et al., "CD38(-CELLS - A POPULATION OF T-CELLS WITH IMMUNE REGULATORY ACTIVITIES IN-VITRO() CD45RB(LOW) CD4(+) T)", European Journal of Immunology, 28(11), 1998, pp. 3435-3447

Abstract

An antibody reactive with CD38 revealed both phenotypic and functional heterogeneity amongst CD45RB(low) cells. Functional analysis of the CD38(+) and CD38(-) fractions showed that the latter contained T cellswhich responded to recall antigens and produced high levels of cytokine in response to polyclonal stimulation. In contrast, the CD38(+) population failed to proliferate or to produce detectable levels of cytokines. Despite appearing unresponsive, the CD38(+) population significantly inhibited anti-CD3-induced proliferation and cytokine secretion by the reciprocal CD38- population. Immune suppression required stimulation through the TCR and was dependent on a physical interaction between regulatory and responding CD4(+) populations. It did not involve killing of the responding T cells or secretion of IL-10 or TGF-beta. Despite some similarities there is no direct correlation between the in vitro suppression characteristic of the CD38(+) CD45RB(low) subset and in vivo suppression which has been shown to be mediated by unseparatedCD45RB(low) CD4(+) T cells. However, these results demonstrate that two functionally distinct subsets of T cells, reside within the antigen-exposed or CD45RB(low) CD4(+) T cell population and are thus generated in vivo: (1) conventional memory T cells which proliferate and secrete cytokines in response to activation and (2) a population of regulatory T cells which inhibit T cell activation in vitro. Antibodies reactive with CD38 may provide a useful tool with which to study the role of these T cell subsets in the induction and regulation of the immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:52:27