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Titolo:
VISCERAL FAT ACCUMULATION IS AN IMPORTANT DETERMINANT OF PAI-1 LEVELSIN YOUNG, NONOBESE MEN AND WOMEN - MODULATION BY CROSS-SEX HORMONE ADMINISTRATION
Autore:
GILTAY EJ; ELBERS JMH; GOOREN LJG; EMEIS JJ; KOOISTRA T; ASSCHEMAN H; STEHOUWER CDA;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DEPT ENDOCRINOL,DIV ANDROL,POB 7057 NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,INST ENDOCRINOL REPROD & METAB NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,INST CARDIOVASC RES NL-1007 MB AMSTERDAM NETHERLANDS TNO,GAUBIUS INST,PG LEIDEN NETHERLANDS
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 11, volume: 18, anno: 1998,
pagine: 1716 - 1722
SICI:
1079-5642(1998)18:11<1716:VFAIAI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; ADIPOSE-TISSUE DISTRIBUTION; TO-MALE TRANSSEXUALS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ALPHA-2-MACROGLOBULIN RECEPTOR; MYOCARDIAL-INFARCTION; FIBRINOLYTIC-ACTIVITY; LUTEINIZING-HORMONE; VASCULAR-DISEASE;
Keywords:
PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1; VISCERAL FAT ACCUMULATION; INSULIN SENSITIVITY; SEX HORMONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Giltay et al., "VISCERAL FAT ACCUMULATION IS AN IMPORTANT DETERMINANT OF PAI-1 LEVELSIN YOUNG, NONOBESE MEN AND WOMEN - MODULATION BY CROSS-SEX HORMONE ADMINISTRATION", Arteriosclerosis, thrombosis, and vascular biology, 18(11), 1998, pp. 1716-1722

Abstract

Increased plasminogen activator inhibitor type-1 (PAI-1) levels, leading to impaired fibrinolysis, are associated with increased visceral fat in middle-aged and obese subjects. It is unknown, however, whether this association is independent of other disturbances clustered in theinsulin resistance syndrome. We analyzed this association in young, nonobese transsexual men and women before and after administration of cross-sex steroids, which potentially influence many elements of the insulin resistance syndrome, including PAI-I levels and visceral fat accumulation. We assessed the visceral fat area (by MRT); total body fat;insulin sensitivity (with a glucose clamp technique): and plasma levels of PAI-1, insulin, and triglycerides in young (<37 years old), nonobese (body mass index <28 kg/m(2)), healthy men (n=18) and women (n=15) before and after 12 months of cross-sex hormone administration. Men were treated with ethinyl estradiol 100 mu g/d plus cyproterone acetate 100 mg/d, and women were treated with testosterone esters 250 mg IM every 2 weeks. At baseline, only visceral fat area was significantly correlated with plasma PAI-1 levels in both men (r=0.57, P=0.03) and women (r=0.59, P=0.03). In multivariate linear regression analysis, thisassociation was independent of total body fat, insulin sensitivity, and plasma levels of triglycerides and insulin. After 12 months of cross-sex hormone administration, the plasma PAI-1 levels were no longer correlated with visceral far (which had increased). We conclude that inyoung, nonobese men and women, visceral fat area is an important determinant of plasma PAI-I levels. After cross-sex hormone administration, this association was no longer demonstrable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:49:41