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Titolo:
LUNG DISTRIBUTION OF INTRATRACHEALLY INSTILLED TC-99M-TOBRAMYCIN-SURFACTANT MIXTURE IN RATS WITH A KLEBSIELLA-PNEUMONIAE LUNG INFECTION
Autore:
VANTVEEN A; WOLLMER P; NILSSON LE; GOMMERS D; MOUTON JW; KOOIJ PPM; LACHMANN B;
Indirizzi:
ERASMUS UNIV,DEPT ANAESTHESIOL ROTTERDAM NETHERLANDS ERASMUS UNIV,DEPT ANAESTHESIOL ROTTERDAM NETHERLANDS MALMO UNIV HOSP,DEPT CLIN PHYSIOL MALMO SWEDEN ERASMUS UNIV,DEPT CLIN MICROBIOL ROTTERDAM NETHERLANDS ERASMUS UNIV,DEPT NUCL MED ROTTERDAM NETHERLANDS
Titolo Testata:
ACP. Applied cardiopulmonary pathophysiology
fascicolo: 2, volume: 7, anno: 1998,
pagine: 87 - 94
SICI:
0920-5268(1998)7:2<87:LDOIIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY SURFACTANT; EXOGENOUS SURFACTANT; CYSTIC-FIBROSIS; CEFTAZIDIME; TOBRAMYCIN; RABBITS; ENDOTRACHEAL; PENTAMIDINE; GENTAMICIN; DELIVERY;
Keywords:
PULMONARY SURFACTANT; SURFACTANT AS CARRIER; TC-99M-TOBRAMYCIN; LUNG DISTRIBUTION; LUNG INFECTION; LOCAL ANTIMICROBIAL THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A. Vantveen et al., "LUNG DISTRIBUTION OF INTRATRACHEALLY INSTILLED TC-99M-TOBRAMYCIN-SURFACTANT MIXTURE IN RATS WITH A KLEBSIELLA-PNEUMONIAE LUNG INFECTION", ACP. Applied cardiopulmonary pathophysiology, 7(2), 1998, pp. 87-94

Abstract

It has been proposed to use pulmonary surfactant as vehicle for intratracheally instilled antibiotics to achieve a more peripheral and homogeneous antibiotic distribution within the lungs. The present study describes a method for labeling tobramycin with technetium (Tc-99m-tobramycin) and investigates lung distribution of intratracheally instilledTc-99m-tobramycin with and without the use of surfactant as vehicle in rats infected with Klebsiella pneumoniae. Twenty-four hours after infection animals received intratracheally 1 ml/kg of Tc-99m-tobramycin-surfactant mixture (n = 6), or Tc-99m-tobramycin alone (n = 6). Five minutes after instillation animals were killed and lungs were excised, frozen and cut in 1 mm thick slices. Computer assisted autoradiographswere analyzed to evaluate Tc-99m-tobramycin distribution. Spatial distribution of radioactivity represented as the mean fractional area with radioactivity above threshold x 100%, was 47% in the Tc-99m-tobramycin-surfactant group vs 36% in the Tc-99m-tobramycin (p less than or equal to 0.05). It is concluded that spreading of intratracheally instilled Tc-99m-tobramycin through infected lungs is increased when surfactant is used as vehicle.

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Documento generato il 09/07/20 alle ore 14:00:39