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Titolo:
LOCAL-DELIVERY OF CHEMOTHERAPEUTIC-AGENTS IN PERIODONTAL THERAPY - HAS ITS TIME ARRIVED
Autore:
FINKELMAN RD; WILLIAMS RC;
Indirizzi:
ASTRA PHARMACEUT LP,CLIN RES,MED AFFAIRS,50 OTIS ST WESTBOROUGH MA 01581 UNIV N CAROLINA,DEPT PERIODONTOL CHAPEL HILL NC 00000
Titolo Testata:
Journal of clinical periodontology
fascicolo: 11, volume: 25, anno: 1998,
parte:, 2
pagine: 943 - 946
SICI:
0303-6979(1998)25:11<943:LOCIPT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TETRACYCLINE FIBER THERAPY; 25-PERCENT DENTAL GEL; MULTICENTER COMPARATIVE-EVALUATION; RELEASE DOSAGE FORM; ANTIMICROBIAL IRRIGATION; ADULT PERIODONTITIS; SUBGINGIVAL APPLICATION; DEEP POCKETS; CHLORHEXIDINE; METRONIDAZOLE;
Keywords:
ANTIINFECTIVE AGENTS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS, PERIODONTITIS THERAPY; ROOT PLANING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Finkelman e R.C. Williams, "LOCAL-DELIVERY OF CHEMOTHERAPEUTIC-AGENTS IN PERIODONTAL THERAPY - HAS ITS TIME ARRIVED", Journal of clinical periodontology, 25(11), 1998, pp. 943-946

Abstract

The concept of locally-delivering chemotherapeutic agents to the periodontal pocket as a method to treat periodontal disease has been studied for over 20 years. A number of locally-delivered chemotherapeutic agents in periodontal therapy are either currently available or under in investigation. Clinical efficacy derives from sustained-release technology to maintain an effective concentration of drug within the periodontal pocket for a clinically relevant length of time. Studied drugs have mainly been antimicrobials, both antibiotics and antiseptics. Most agents have been tested as adjuncts to scaling and root planing; a few have been studied as stand-alone monotherapies. Collectively, the data indicate that the use of locally-delivered antimicrobials as adjuncts results in a significant increase in the reduction of probing depth compared with scaling and root planing alone. In other trials, results in reducing probing depth following the use of stand-alone locally-delivered antimicrobials have been equivalent to those of scaling and root planing over a specified time. This Symposium was organized to present the current state-of-the-art with regard to the use of locally-delivered antimicrobials in the treatment of periodontal disease. 5 experts in the field who have had considerable experience in studying locally-delivered antimicrobials presented data. These speakers reviewed the clinical findings regarding efficacy of 5 different antimicrobial agents. An ensuing panel discussion was to consider treatment recommendations for locally-delivered antimicrobials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 20:35:42