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Titolo:
MAINTENANCE PHASE EFFICACY OF SERTRALINE FOR CHRONIC DEPRESSION - A RANDOMIZED CONTROLLED TRIAL
Autore:
KELLER MB; KOCSIS JH; THASE ME; GELENBERG AJ; RUSH AJ; KORAN L; SCHATZBERG A; RUSSELL J; HIRSCHFELD R; KLEIN D; MCCULLOUGH JP; FAWCETT JA; KORNSTEIN S; LAVANGE L; HARRISON W;
Indirizzi:
BROWN UNIV,BUTLER HOSP,DEPT PSYCHOL & HUMAN BEHAV,345 BLACKSTONE BLVDPROVIDENCE RI 02906 BROWN UNIV,BUTLER HOSP,DEPT PSYCHIAT PROVIDENCE RI 02912 CORNELL UNIV,SCH MED,DEPT PSYCHIAT NEW YORK NY 10021 UNIV PITTSBURGH,DEPT PSYCHIAT PITTSBURGH PA 00000 WESTERN PSYCHIAT INST & CLIN,DEPT PSYCHIAT PITTSBURGH PA 00000 UNIV ARIZONA,DEPT PSYCHIAT TUCSON AZ 00000 UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT DALLAS TX 00000 STANFORD UNIV,SCH MED,DEPT PSYCHIAT STANFORD CA 94305 UNIV TEXAS,MED BRANCH,DEPT PSYCHIAT GALVESTON TX 77550 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PSYCHIAT RICHMOND VA 23298 RUSH INST MENTAL WELL BEING,DEPT PSYCHIAT CHICAGO IL 00000 QUINTILES,DEPT PSYCHIAT RES TRIANGLE PK NC 00000 PFIZER INC,DEPT PSYCHIAT NEW YORK NY 00000 COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT NEW YORK NY 10032
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 19, volume: 280, anno: 1998,
pagine: 1665 - 1672
SICI:
0098-7484(1998)280:19<1665:MPEOSF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECURRENT DEPRESSION; MAJOR DEPRESSION; DRUG-THERAPY; CONTINUATION; PREVENTION; DISABILITY; DISORDERS; OUTCOMES; BURDEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Keller et al., "MAINTENANCE PHASE EFFICACY OF SERTRALINE FOR CHRONIC DEPRESSION - A RANDOMIZED CONTROLLED TRIAL", JAMA, the journal of the American Medical Association, 280(19), 1998, pp. 1665-1672

Abstract

Context.-The chronic form of major depression is associated with a high rate of prevalence and disability, but no controlled research has examined the impact of long-term treatment on the course and burden of illness. Objective.-To determine if maintenance therapy with sertraline hydrochloride can effectively prevent recurrence of depression in the high-risk group of patients experiencing chronic major depression ormajor depression with antecedent dysthymic disorder (''double depression''). Design.-A 76-week randomized, double-blind, parallel-group study, conducted from September 1993 to November 1996, Setting.-Outpatient psychiatric clinics at 10 academic medical centers and 2 clinical research centers. Intervention.-Maintenance treatment with either sertraline hydrochloride (n = 77) in flexible doses up to 200 mg or placebo (n = 84), Patients.-A total of 161 outpatients with chronic major or double depression who responded to sertraline in a 12-week, double-blind, acute-phase treatment trial and continued to have a satisfactory therapeutic response during a subsequent 4-month continuation phase. Main Outcome Measure.-Time to recurrence of major depression. Results.-Sertraline afforded significantly greater prophylaxis against recurrencethan did placebo (5 [6%] of 77 in the sertraline group vs 19 [23%] of84 in the placebo group; P = .002 for the log-rank test of time-to-recurrence distributions). Clinically significant depressive symptoms reemerged in 20 (26%) of 77 patients treated with sertraline vs 42 (50%)of 84 patients who received placebo (P=.001), With use of a Cox proportional hazards model, patients receiving placebo were 4.07 times morelikely (95% CI, 1.51-10.95; P=.005) to experience a depression recurrence, after adjustment for study site, type of depression, and randomization strata. Conclusions.-Maintenance therapy with sertraline is well tolerated and has significant efficacy in preventing recurrence or reemergence of depression in chronically depressed patients.

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Documento generato il 04/04/20 alle ore 02:30:01