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Titolo:
MORPHINE APPLICATION TO PERIPHERAL-TISSUES MODULATES NOCICEPTIVE JAW REFLEX
Autore:
BAKKE M; HU JW; SESSLE BJ;
Indirizzi:
UNIV COPENHAGEN,FAC HLTH SCI,SCH DENT,DEPT ORAL FUNCT & PHYSIOL,20 NORRE ALLE DK-2200 COPENHAGEN N DENMARK UNIV TORONTO,FAC DENT,DEPT ORAL PHYSIOL TORONTO ON M5G 1G6 CANADA
Titolo Testata:
NeuroReport
fascicolo: 14, volume: 9, anno: 1998,
pagine: 3315 - 3319
SICI:
0959-4965(1998)9:14<3315:MATPMN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY IRRITANT APPLICATION; RAT TEMPOROMANDIBULAR-JOINT; MUSCLE-ACTIVITY; PAIN; MECHANISMS; ANALGESIA; OPIOIDS; MODEL; NECK;
Keywords:
ANTINOCICEPTIVE EFFECTS; JAW MUSCLE ACTIVITY; MORPHINE; MUSTARD OIL; NALOXONE; PERIPHERAL OPIOID RECEPTORS; TEMPOROMANDIBULAR JOINT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M. Bakke et al., "MORPHINE APPLICATION TO PERIPHERAL-TISSUES MODULATES NOCICEPTIVE JAW REFLEX", NeuroReport, 9(14), 1998, pp. 3315-3319

Abstract

THIS study assessed the effect of peripherally applied opioids on theelectromyographic activity reflexly evoked in digastric and masseter muscles by injection of the small-fiber excitant and inflammatory irritant mustard oil (MO) into the temporomandibular joint. In 39 anaesthetized rats, local pretreatment of joint tissues with morphine (15 nmol) significantly depressed the jaw muscle responses compared with saline, and the depression was antagonized by simultaneous local injection of the opiate antagonist naloxone (2.7 nmol); systemic morphine pretreatment (15 nmol, i.v.) did not influence the muscle responses. The naloxone-reversible depression of the MO-evoked muscle responses by local, but not systemic morphine, supports the presence of peripheral opioid receptors that may have a role in modulating nociceptive responses. (C) 1998 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:13:59