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Titolo:
AORTIC ATHEROSCLEROSIS AS A SOURCE OF ARTERIAL EMBOLISM
Autore:
MITUSCH R; STIERLE U; SHEIKHZADEH A;
Indirizzi:
UNIV LUBECK,MED KLIN 2,RATZEBURGER ALLEE 160 D-23538 LUBECK GERMANY UNIV LUBECK,MED KLIN 2 D-23538 LUBECK GERMANY UNIV GREIFSWALD,KLINIKUM HANSESTADT STRALSUND GMBH,AKAD LEHRKRANKENHAUS D-18435 STRALSUND GERMANY CURSCHMANN KLIN D-23669 TIMMENDORFER STR GERMANY
Titolo Testata:
Zeitschrift fur Kardiologie
fascicolo: 10, volume: 87, anno: 1998,
pagine: 789 - 796
SICI:
0300-5860(1998)87:10<789:AAAASO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
GER
Soggetto:
LEFT-HEART CATHETERIZATION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; THORACIC AORTA; ASCENDING AORTA; CHOLESTEROL EMBOLIZATION; SYSTEMIC EMBOLIZATION; ATHEROMATOUS EMBOLIZATION; CARDIOPULMONARY BYPASS; MYOCARDIAL-INFARCTION; VASCULAR EVENTS;
Keywords:
AORTA; THROMBOGENIC AORTIC ARCH; ATHEROSCLEROSIS; AORTIC PLAQUE; TRANSESOPHAGEAL ECHOCARDIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
96
Recensione:
Indirizzi per estratti:
Citazione:
R. Mitusch et al., "AORTIC ATHEROSCLEROSIS AS A SOURCE OF ARTERIAL EMBOLISM", Zeitschrift fur Kardiologie, 87(10), 1998, pp. 789-796

Abstract

Aortic atherosclerosis has early been recognized as a potential source of embolism. The histological finding of cholesterol clefts in smallend-arteries characterized the entity of cholesterol embolism. The clinical picture was extremely variable and the diagnosis was frequentlyestablished post-mortem or by means of invasive although insensitive procedures including biopsy and angiography. Therefore, cholesterol embolism was thought to be rare. With the routine use of transesophagealechocardiography for the diagnostic workup of arterial embolism, aortic atherosclerosis was shown to be the source of otherwise unexplainable embolism. Cross-sectional studies demonstrated an independent association between prominent plaques of more than 4 to 5 mm of thickness or plaques with mobile components in the aortic arch. In follow-up studies, the risk of embolic events in patients with this kind of lesions exceeded 10 % per patient-year The results of pathological studies were consistent with these findings showing that ulcerated complex plaques carry an independent risk for embolic events. Apart from spontaneousembolism, atherosclerosis of the proximal aorta was shown to be a cause of embolic complications during cardiac surgery and catheterizationprocedures which involve the aorta. Medical treatment for the prevention of embolism in atherosclerotic disease of the aorta has not been studied systematically. In a variant form of aortic atherosclerosis consisting of mobile pedunculated thrombi inserting on relatively small plaques, anticoagulant therapy has proved to be useful in small numbersof patients. Recurrent embolic events could be prevented and regression of the thrombotic masses has been observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:38:17