Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MATURATION OF FATTY-ACID AND CARBOHYDRATE-METABOLISM IN THE NEWBORN HEART
Autore:
MAKINDE AO; KANTOR PF; LOPASCHUK GD;
Indirizzi:
UNIV ALBERTA,FAC MED,DEPT PEDIAT,LIPID & LIPOPROT RES GRP,CARDIOVASC RES GRP EDMONTON AB T6G 2S2 CANADA UNIV ALBERTA,FAC MED,DEPT PEDIAT,LIPID & LIPOPROT RES GRP,CARDIOVASC RES GRP EDMONTON AB T6G 2S2 CANADA UNIV ALBERTA,FAC MED,DEPT PHARMACOL EDMONTON AB T6G 2S2 CANADA
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 188, anno: 1998,
pagine: 49 - 56
SICI:
0300-8177(1998)188:1-2<49:MOFACI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-COA CARBOXYLASE; 5'-AMP-ACTIVATED PROTEIN-KINASE; CELLULAR ENERGY METABOLISM; CHROMOSOMAL LOCALIZATION; PALMITATE OXIDATION; GLUCOSE-TRANSPORTER; ENZYME-ACTIVITIES; FETAL DEVELOPMENT; SKELETAL-MUSCLE; RABBIT HEART;
Keywords:
5'AMP ACTIVATED PROTEIN KINASE; ACETYL COA CARBOXYLASE; NEWBORN; FATTY ACID OXIDATION; GLYCOLYSIS; GLUCOSE OXIDATION; FATTY ACID OXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A.O. Makinde et al., "MATURATION OF FATTY-ACID AND CARBOHYDRATE-METABOLISM IN THE NEWBORN HEART", Molecular and cellular biochemistry, 188(1-2), 1998, pp. 49-56

Abstract

During fetal life, myocardial ATP is derived predominantly from glycolysis and lactate oxidation. Following birth, a rapid maturational increase in fatty acid oxidation occurs along with a decline in glycolytic and lactate oxidative rates, thus changing the major source of myocardial ATP production. This shift in energy substrate preference occursin response to changes in the circulating substrate content of newborn plasma with the onset of suckling, and is also due to alterations incirculating levels of hormones, such as insulin and glucagon. Important changes in subcellular regulatory mechanisms of both fatty acid andcarbohydrate metabolism in the heart also characterize this response. This review deals with recent advances in the understanding of these subcellular mechanisms which regulate this important shift in myocardial energy metabolism, with particular emphasis on the molecular eventsoccurring in the heart during the transition from fetal to newborn life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 01:49:25