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Titolo:
FUNCTIONAL AND PHYSICAL ASSOCIATION OF A CELL-SURFACE PHOSPHOLIPID AND INTERLEUKIN-2 RECEPTOR P55(ALPHA) SUBUNITS
Autore:
SARAGOVI HU; BHANDOOLA A; MOREAU JL; LAVINE N; GAGNON M; LEMERCIER MM; THEZE J;
Indirizzi:
MCGILL UNIV,DEPT PHARMACOL & THERAPEUT,3655 DRUMMOND 1320 MONTREAL PQH3G 1Y6 CANADA MCGILL CANC CTR MONTREAL PQ H3G 1Y6 CANADA UNIV PENN,SCH MED,DEPT PATHOL & LAB MED PHILADELPHIA PA 19104 INST PASTEUR PARIS 15 FRANCE
Titolo Testata:
Biochimica et biophysica acta. Biomembranes
fascicolo: 1-2, volume: 1414, anno: 1998,
pagine: 51 - 64
SICI:
0005-2736(1998)1414:1-2<51:FAPAOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASES; MURINE IL-2 RECEPTOR; GAMMA-CHAIN; SIGNAL-TRANSDUCTION; BETA-CHAIN; MONOCLONAL-ANTIBODIES; ALPHA-CHAIN; GROWTH; IDENTIFICATION; EXPRESSION;
Keywords:
CYTOKINE; RECEPTOR; ANTIBODY; LIPID; MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
H.U. Saragovi et al., "FUNCTIONAL AND PHYSICAL ASSOCIATION OF A CELL-SURFACE PHOSPHOLIPID AND INTERLEUKIN-2 RECEPTOR P55(ALPHA) SUBUNITS", Biochimica et biophysica acta. Biomembranes, 1414(1-2), 1998, pp. 51-64

Abstract

A phospbatidylcholine-like phospholipid expressed in the outer leaflet of the cell membrane shortly after mitogenic activation of T-cells is described, based on the binding of monoclonal antibody 90.60.3. Expression of the 90.60.3 phospholipid antigen in T-cells is activation-dependent. Once expressed, the 90.60.3 phospholipid is in direct physical association with the interleukin-2 (IL-2) binding domain of IL-2 receptor alpha subunits, but does not affect IL-2 binding. The association is specific, because the 90.60.3 phospholipid is not found in association with other domains of IL-2 receptor alpha subunits, of near IL-2receptor beta or gamma subunits. Culturing cytokine-dependent cell lines in the presence of monoclonal antibody 90.60.3 potentiates IL-2-dependent cell survival and proliferation in a dose-dependent manner. Incontrast, IL-4-dependent responses are not potentiated. Taken together, the data suggest that specific plasma membrane phospholipids expressed in the outer leaflet after T-cell activation associate with the IL-2 binding domain of IL-2 receptor alpha subunits (and perhaps other cytokine receptors), and may play a role in regulating receptor mobility or signal transduction. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:21:32