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Titolo:
THE EFFECT OF THE LIPID-A ANALOG E5531 ON PHOSPHOLIPID MEMBRANE-PROPERTIES
Autore:
ASAI Y; IWAMOTO K; WATANABE S;
Indirizzi:
EISAI & CO LTD,FORMULAT RES LAB,TAKEHAYA MACHI,KAWASHIMA CHO GIFU 50161 JAPAN EISAI & CO LTD,TSUKUBA RES LABS TSUKUBA IBARAKI 30026 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 1-2, volume: 438, anno: 1998,
pagine: 15 - 20
SICI:
0014-5793(1998)438:1-2<15:TEOTLA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERIAL-ENDOTOXIN; PHASE-TRANSITION; LIPOPOLYSACCHARIDE; MONOLAYERS; LIPOSOMES; BINDING; BILAYERS; TRIOLEIN; FLUIDITY;
Keywords:
DPPC; E5531; PHOSPHOLIPID MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Y. Asai et al., "THE EFFECT OF THE LIPID-A ANALOG E5531 ON PHOSPHOLIPID MEMBRANE-PROPERTIES", FEBS letters, 438(1-2), 1998, pp. 15-20

Abstract

In order to determine the effect of the lipid A analog, E5531, on phospholipid membranes, we used dipalmitoylphosphatidylcholine (DPPC) andinvestigated the physicochemical interaction between E5531 and DPPC membranes. E5531 and DPPC are miscible in the bulk phase at 25 degrees C. Within the E5531 mole fraction range (X-E5531) Of 0-0.5, E5531 decreased the zeta potentials of DPPC membranes but did not change the size of the DPPC liposomes. E5531/DPPC mixtures formed liposome-like structures, E5531 increased the fluidity of the DPPC membrane and decreased pyrene diffusion in the membrane. E5531 decreased the phase transition temperature and the cooperative interactions between DPPC molecules, These effects of E5531 on phospholipid membranes were different fromthose of lipid A from Escherichia coli and Salmonella minnesota. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:25:22