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Titolo:
ANTIINFLAMMATORY ACTIVITY OF THE PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONIST A-85783
Autore:
TRAVERS J; PEI Y; MORIN SM; HOOD AF;
Indirizzi:
INDIANA UNIV,JAMES WHITCOMB RILEY HOSP CHILDREN,SCH MED,HB WELLS CTR PEDIAT RES,RM 2659 INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT DERMATOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PEDIAT INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHARMACOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PATHOL INDIANAPOLIS IN 46202
Titolo Testata:
Archives of dermatological research (Print)
fascicolo: 10, volume: 290, anno: 1998,
pagine: 569 - 573
SICI:
0340-3696(1998)290:10<569:AAOTPR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAF-ACETHER; HUMAN-SKIN; IDENTIFICATION; KERATINOCYTES; MICE;
Keywords:
PLATELET-ACTIVATING FACTOR; PLATELET-ACTIVATING FACTOR RECEPTOR; PHORBOL MYRISTIC ACETATE; DERMATITIS; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J. Travers et al., "ANTIINFLAMMATORY ACTIVITY OF THE PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONIST A-85783", Archives of dermatological research (Print), 290(10), 1998, pp. 569-573

Abstract

Accumulating evidence suggests an important role for the lipid mediator, platelet-activating factor (PAF), in cutaneous inflammation. In these studies the antiinflammatory effects of the potent and selective lipophilic PAF receptor antagonist A-85783 topically applied to the ventral ears of male Wistar rats were assessed. Intradermal injections ofPAF into rat ears resulted in cutaneous inflammation as assessed by both ear thickness measurements and histological evaluation. Pretreatment of the ears with A-85783 resulted in an inhibition of subsequent PAF-induced inflammation. A-85783 treatment also inhibited phorbol myristic acetate-induced cutaneous inflammation, suggesting that the PAF receptor is involved in the etiology of this experimental dermatitis. These findings demonstrate that epicutaneous A-85783 is an appropriate tool to study the role of the PAF receptor in cutaneous inflammation, and suggest the possible clinical utility of this new class of antiinflammatory agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:17:30