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Titolo:
PREDICTION OF VERTEBRAL FAILURE LOADS FROM SPINAL AND FEMORAL DUAL-ENERGY X-RAY ABSORPTIOMETRY, AND CALCANEAL ULTRASOUND - AN IN-SITU ANALYSIS WITH INTACT SOFT-TISSUES
Autore:
LOCHMULLER EM; ECKSTEIN F; KAISER D; ZELLER JB; LANDGRAF J; PUTZ R; STELDINGER R;
Indirizzi:
UNIV MUNICH,FRAUENKLIN 1,MAISTR 11 D-80337 MUNICH GERMANY UNIV MUNICH,ANAT ANSTALT D-80337 MUNICH GERMANY
Titolo Testata:
Bone (New York, N.Y.)
fascicolo: 5, volume: 23, anno: 1998,
pagine: 417 - 424
SICI:
8756-3282(1998)23:5<417:POVFLF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE COMPUTED-TOMOGRAPHY; BONE-MINERAL DENSITY; NATIONAL-OSTEOPOROSIS-FOUNDATION; FRACTURE RISK PREDICTION; PHOTON-ABSORPTIOMETRY; COMPRESSIVE STRENGTH; LUMBAR SPINE; BODY STRENGTH; IN-VITRO; WOMEN;
Keywords:
VERTEBRAL FRACTURE; BONE MINERAL DENSITY; DUAL-ENERGY X-RAY ABSORPTIOMETRY; FAILURE LOAD; OSTEOPOROSIS; ULTRASOUND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Lochmuller et al., "PREDICTION OF VERTEBRAL FAILURE LOADS FROM SPINAL AND FEMORAL DUAL-ENERGY X-RAY ABSORPTIOMETRY, AND CALCANEAL ULTRASOUND - AN IN-SITU ANALYSIS WITH INTACT SOFT-TISSUES", Bone (New York, N.Y.), 23(5), 1998, pp. 417-424

Abstract

The objective of the current study was to determine the correlation of spinal and femoral dual-energy X-ray absorptiometry (DXA) and calcaneal ultrasound, measured in situ with intact soft tissues, with the invitro failure loads of lumbar vertebral bodies. Forty-nine cadavers with intact skin and soft tissues (32 men aged 82.1 +/- 9.0 years, 17 women aged 83.1 +/- 10.1 years) were examined. The bone mineral content(BMC), the projectional area, and the bone mineral density (BMD) of the lumbar spine and proximal femur were determined with DXA, and the ultrasonic properties of the calcaneus with quantitative calcaneal ultrasound, The fourth lumbar vertebra was then excised with adjacent intervertebral disks and its mechanical failure load determined, using a materials testing machine. Absolute fracture loads were significantly higher in men than in women, but they were similar after adjusting for body weight and height, Spinal DXA was significantly associated with vertebral failure load (r = 0.62 combined; r = 0.54 men; r = 0.58 women). Femoral DXA (r = 0.46) and calcaneal ultrasound (r = 0.48) showed somewhat lower correlation coefficients, with the speed of sound (SOS) being able to add predictive information in a stepwise regression model. Normalizing the vertebral failure loads to body weight and height reduced the correlations,,vith only spinal DXA yielding a significant relationship. Our data suggest that previous in vitro studies may have overestimated the association between spinal DXA and vertebral failureloads, presumably because measurements were performed on excised bones, but not in situ in the presence of soft tissue inhomogeneity. The results indicate that, even in a population of old age and under in situ conditions, spinal DXA may still be somewhat better than femoral DXAand calcaneal ultrasound in predicting vertebral failure loads. (C) 1998 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:50:26