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Titolo:
BASIC FIBROBLAST-GROWTH-FACTOR PROTECTED FOREBRAIN AGAINST ISCHEMIA-REPERFUSION DAMAGE IN RATS
Autore:
LIU X; ZHU XZ;
Indirizzi:
CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL SHANGHAI 200031PEOPLES R CHINA CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL SHANGHAI 200031PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 6, volume: 19, anno: 1998,
pagine: 527 - 530
SICI:
0253-9756(1998)19:6<527:BFPFAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; HIPPOCAMPAL-NEURONS; NITRIC-OXIDE; GLUTAMATE; DOPAMINE;
Keywords:
BASIC FIBROBLAST GROWTH FACTOR; REPERFUSION INJURY; VISUAL CORTEX; DOPAMINE; WATER; SODIUM; POTASSIUM; HIGH PRESSURE LIQUID CHROMATOGRAPHY; CORPUS STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
X. Liu e X.Z. Zhu, "BASIC FIBROBLAST-GROWTH-FACTOR PROTECTED FOREBRAIN AGAINST ISCHEMIA-REPERFUSION DAMAGE IN RATS", Zhongguo yaoli xuebao, 19(6), 1998, pp. 527-530

Abstract

AIM: To study the effect of basic fibroblast growth factor (bFGF) on acute forebrain ischemia-reperfusion injury in rats. METHODS: Both vertebral arteries were occluded by electrocautery and severe but transient bilateral cerebral ischemia was produced by clamping both common carotid arteries for 20 min in rats. The contents of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in striatum were determined by HPLC with electrochemic detector (HPLC-EC) at 3, 6, 12, 24 h after the onset of reperfusion. The contents of sodium, potassium in forebrain were determined by atomic absorption spectro-photometric method at 6-h reperfusion. Morphological changes of the striatum were also examined. RESULTS: At 6-h reperfusion, the DA content in striatum decreased from (99 +/- 16) mu g . g(-1)(protein) in sham-operation group to (70 +/-20) mu g . g(-1) (protein); the water and the sodium contents in forebrain increased from 77.34% +/- 0.19% to 79.6% +/- 0.6% and from (9.3 /- 0.6) to (10.5 +/- 0.6) mg . g(-1) (dry weight), respectively, bFGF(iv 45 mu g . kg(-1) . h(-1) for 3 h) from the start of reperfusion prevented the decrease of DA in striatum and the increases of water andsodium contents in forebrain. Histological examination also indicatedthat bFGF ameliorated the injury of neurons. CONCLUSION: bFGF prevented the brain from injury of ischemia and reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:26:01