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Titolo:
WHOLE HEMISPHERE AUTORADIOGRAPHY OF THE POSTMORTEM HUMAN BRAIN
Autore:
HALL H; HALLDIN C; FARDE L; SEDVALL G;
Indirizzi:
KAROLINSKA HOSP,DEPT CLIN NEUROSCI,PSYCHIAT SECT,KAROLINSKA INST S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Nuclear medicine and biology
fascicolo: 8, volume: 25, anno: 1998,
pagine: 715 - 719
SICI:
0969-8051(1998)25:8<715:WHAOTP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; DOPAMINE RECEPTOR-BINDING; C-11 BETA-CIT; D-2-DOPAMINE RECEPTORS; POTENTIAL RADIOLIGAND; 5-HT1A RECEPTORS; I-125 EPIDEPRIDE; D2 RECEPTORS; RAT-BRAIN; PET;
Keywords:
AUTORADIOGRAPHY; HUMAN BRAIN; DOPAMINE RECEPTORS; SEROTONIN RECEPTORS; POSTMORTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Hall et al., "WHOLE HEMISPHERE AUTORADIOGRAPHY OF THE POSTMORTEM HUMAN BRAIN", Nuclear medicine and biology, 25(8), 1998, pp. 715-719

Abstract

Whole hemisphere autoradiography (WHA) with selective high-affinity radioligands is a new tool in studying the distribution of receptors and of other neuronal components postmortem in brains from controls vs. subjects with psychiatric and neurologic diseases. WHA can be performed with several different isotopes (e.g., H-3, I-125 and C-11), and is in addition to characterization studies also used as a tool in early radioligand development. Moreover, using this technique, high-resolution images are obtained that are complementary to those obtained in vivowith e.g., PET and SPECT. Results on dopamine and serotonin receptor subtypes as well as of their transporters show that WHA is a very suitable technique for the detailed characterization of the distribution in the whole human brain. NUCL MED BIOL 25;8:715-119, 1998. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:47:33