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Titolo:
EXPRESSION OF THE P2X(7)-RECEPTOR SUBUNIT IN NEURONS OF THE RAT RETINA
Autore:
BRANDLE U; KOHLER K; WHEELERSCHILLING TH;
Indirizzi:
UNIV TUBINGEN,HOSP EYE,DEPT PATHOPHYSIOL VIS & NEUROOPHTHALMOL,DIV EXPT OPHTHALMOL,RONTGENWEG 11 D-72076 TUBINGEN GERMANY UNIV TUBINGEN,HOSP EYE,DEPT PATHOPHYSIOL VIS & NEUROOPHTHALMOL,DIV EXPT OPHTHALMOL D-72076 TUBINGEN GERMANY UNIV TUBINGEN,DEPT OTOLARYNGOL D-72076 TUBINGEN GERMANY
Titolo Testata:
Molecular brain research
fascicolo: 1, volume: 62, anno: 1998,
pagine: 106 - 109
SICI:
0169-328X(1998)62:1<106:EOTPSI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GATED ION CHANNELS; ANGIOTENSIN-II; P-2X RECEPTOR; EXTRACELLULAR ATP; SENSORY NEURONS; NERVOUS-SYSTEM; GANGLION-CELLS; CURRENTS; FAMILY;
Keywords:
P2X(7)-RECEPTOR; PURINERGIC RECEPTORS; RAT; RETINA; CHOROID; IMMUNOHISTOCHEMISTRY; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
U. Brandle et al., "EXPRESSION OF THE P2X(7)-RECEPTOR SUBUNIT IN NEURONS OF THE RAT RETINA", Molecular brain research, 62(1), 1998, pp. 106-109

Abstract

Despite the considerable evidence of signaling by extracellular nucleotides in other sensory systems, few studies have been undertaken in the eye. Molecular and immunohistochemical methods were used to demonstrate the expression and cellular localization of the P2X(7) receptor subunit in the retina and choroid. RT-PCR was used for the detection ofP2X(7) subunit mRNA in the rot of different postnatal developmental stages (P23-P210) and revealed the presence of P2X(7)-mRNA in the retina, but not in the choroid. In the adult rat retina, immunolabelling for P2X(7) was detected in a number of cells in the inner nuclear layer (ML) and ganglion cell layer (GCL), suggesting different types of amacrine cells and ganglion cells. These results demonstrate for the firsttime the expression of the P2X(7) receptor in the mammalian retina and furthermore in distinct neuronal cell populations. Our data suggest that extracellular ATP may provide both neuromodulatory and trophic influences on visual processing. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:07:30