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Titolo:
EXPRESSION OF NOVEL POTASSIUM CHANNELS IN THE CHICK BASILAR PAPILLA
Autore:
MASON K; PEALE FV; STONE JS; RUBEL EW; BOTHWELL M;
Indirizzi:
UNIV WASHINGTON,VIRGINIA MERRILL BLOEDEL HEARING RES CTR SEATTLE WA 98195 UNIV WASHINGTON,VIRGINIA MERRILL BLOEDEL HEARING RES CTR SEATTLE WA 98195 UNIV WASHINGTON,DEPT OTORHINOLARYNGOL HEAD & NECK SURG SEATTLE WA 98195 GENENTECH INC,DEPT PATHOL S SAN FRANCISCO CA 94080 UNIV WASHINGTON,DEPT PHYSIOL & BIOPHYS SEATTLE WA 98195
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 125, anno: 1998,
pagine: 120 - 130
SICI:
0378-5955(1998)125:1-2<120:EONPCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCHLEAR HAIR-CELLS; INWARD RECTIFIER; K+ CHANNEL; ACTIN-FILAMENTS; INNER-EAR; MESSENGER-RNAS; BIRD COCHLEA; CURRENTS; CLONING; STEREOCILIA;
Keywords:
POTASSIUM CHANNEL; INNER EAR; COCHLEA; HAIR CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
K. Mason et al., "EXPRESSION OF NOVEL POTASSIUM CHANNELS IN THE CHICK BASILAR PAPILLA", Hearing research, 125(1-2), 1998, pp. 120-130

Abstract

Ionic currents are critical for the functioning of the inner car auditory sensory epithelium. We set out to identify and molecularly clone the genes encoding the channels responsible for several currents in the chick basilar papilla. Here we describe an inward-rectifying K+ channel, cKir2.3, present in both hair cells and support cells in the apical end of the chick basilar papilla. The biophysical properties of thehuman ortholog, hKir2.3, are similar to those of an inward-rectifyingchannel found in the apical end of the chick basilar papilla, suggesting that this channel may contribute to the corresponding current. Additionally, we describe two new members of the Kv6 subfamily of putative regulatory voltage-gated K+ channels, cKv6.2 and cKv6.3, Both are expressed in hair cells in the epical end of the chick basilar papilla: cKv6.2 is also strongly expressed in support cells and in the brain. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:37:32