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Titolo:
IMMUNOGLOBULIN E-DEPENDENT ACTIVE FATAL ANAPHYLAXIS IN MAST CELL-DEFICIENT MICE
Autore:
CHOI IH; SHIN YM; PARK JS; LEE MS; HAN EH; CHAI OH; IM SY; HA TY; LEE HK;
Indirizzi:
CHONBUK NATL UNIV,SCH MED,DEPT IMMUNOL CHONJU 561182 CHONBUK SOUTH KOREA CHONBUK NATL UNIV,SCH MED,DEPT IMMUNOL CHONJU 561182 CHONBUK SOUTH KOREA CHONBUK NATL UNIV,SCH MED,INST MED SCI CHONJU 561182 CHONBUK SOUTH KOREA CHONBUK NATL UNIV,SCH MED,DEPT ANAT CHONJU 561182 CHONBUK SOUTH KOREA CHONNAM NATL UNIV,COLL NAT SCI,DEPT MICROBIOL KWANGJU 500757 SOUTH KOREA CHONNAM NATL UNIV,COLL NAT SCI,HORMONE RES CTR KWANGJU 500757 SOUTH KOREA
Titolo Testata:
The Journal of experimental medicine
fascicolo: 9, volume: 188, anno: 1998,
pagine: 1587 - 1592
SICI:
0022-1007(1998)188:9<1587:IEAFAI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; FC-EPSILON-RI; DISSEMINATED INTRAVASCULAR COAGULATION; EPIDERMAL LANGERHANS CELLS; AFFINITY IGE RECEPTOR; SYSTEMIC-ANAPHYLAXIS; CARDIOPULMONARY CHANGES; MONOCLONAL-ANTIBODY; GAMMA-RIII; EXPRESSION;
Keywords:
MAST CELLS; W/W-V MICE; IMMUNOGLOBULIN E; PLATELET-ACTIVATING FACTOR; PENICILLIN V;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
I.H. Choi et al., "IMMUNOGLOBULIN E-DEPENDENT ACTIVE FATAL ANAPHYLAXIS IN MAST CELL-DEFICIENT MICE", The Journal of experimental medicine, 188(9), 1998, pp. 1587-1592

Abstract

Mast cells have long been believed to be the central effector cells in the development of immunoglobulin (Ig)E-dependent anaphylaxis. In this study, we investigated the role of mast cells in IgE-dependent hapten-induced active fatal anaphylaxis using mast cell-deficient WBB6F1-W/W-v (W/W-v) and congenic normal (+/+) mice. Although a 5-min delay inshock signs and death were observed in W/W-v mice, 100% fatal reactions to penicillin V (Pen V) occurred in both +/+ and W/W-v mice. Administration of monoclonal anti-IL-4 antibody completely prevented the fatal reactions, and the effect of anti-IL-4 was associated with its suppressive activity on Pen V-specific serum levels of IgE, but not IgG. The platelet-activating factor (PAF) antagonist, BN 50739, completely prevented the fatal reactions in both strains of mice. Our kinetic study revealed, in contrast to no elevation of plasma histamine level in W/W-v mice, high levels of PAF in the circulation after challenge in both +/+ and W/W-v mice, albeit to a lesser degree in the latter case. These data indicate that cells other than mast cells are sufficient to induce an IgE-dependent active fatal anaphylaxis by elaborating PAF, which is the critical mediator for fatal murine anaphylaxis.

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Documento generato il 27/01/21 alle ore 01:26:43