Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHOLECYSTOKININ ACTIONS IN THE PARABRACHIAL NUCLEUS - EFFECTS ON THIRST AND SALT APPETITE
Autore:
MENANI JV; JOHNSON AK;
Indirizzi:
UNIV IOWA,DEPT PSYCHOL,11 SEASHORE HALL E IOWA CITY IA 52242 UNIV IOWA,DEPT PSYCHOL IOWA CITY IA 52242 UNIV IOWA,DEPT PHARMACOL IOWA CITY IA 52242 UNIV IOWA,CTR CARDIOVASC IOWA CITY IA 52242 PAULISTA STATE UNIV,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 SAO PAULO BRAZIL
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 5, volume: 44, anno: 1998,
pagine: 1431 - 1437
SICI:
0363-6119(1998)44:5<1431:CAITPN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM APPETITE; AREA POSTREMA; ANGIOTENSIN-II; SOLITARY TRACT; RAT; LESIONS; HYPOTHALAMUS; PROJECTIONS; INHIBITION; DRINKING;
Keywords:
SODIUM CHLORIDE INTAKE; WATER INTAKE; PROGLUMIDE; SODIUM APPETITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.V. Menani e A.K. Johnson, "CHOLECYSTOKININ ACTIONS IN THE PARABRACHIAL NUCLEUS - EFFECTS ON THIRST AND SALT APPETITE", American journal of physiology. Regulatory, integrative and comparative physiology, 44(5), 1998, pp. 1431-1437

Abstract

The present study investigated the effects of bilateral injections ofthe nonselective CCK receptor antagonist proglumide or CCK-8 into thelateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl andwater induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap(5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actionsin the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:23:42