Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ADENOASSOCIATED VIRUS AS A VECTOR FOR LIVER-DIRECTED GENE-THERAPY
Autore:
XIAO WD; BERTA SC; LU MM; MOSCIONI AD; TAZELAAR J; WILSON JM;
Indirizzi:
204 WISTAR,3601 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,INST HUMAN GENE THERAPY PHILADELPHIA PA 19104 UNIV PENN,DEPT MOL & CELLULAR ENGN PHILADELPHIA PA 19104 UNIV PENN,DEPT MED PHILADELPHIA PA 19104 WISTAR INST ANAT & BIOL PHILADELPHIA PA 19104
Titolo Testata:
Journal of virology (Print)
fascicolo: 12, volume: 72, anno: 1998,
pagine: 10222 - 10226
SICI:
0022-538X(1998)72:12<10222:AVAAVF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT ADENOASSOCIATED VIRUS; FACTOR-IX; EXPRESSION; MICE; EFFICIENT; DELIVERY; TRANSDUCTION; PERSISTENT; IMMUNITY; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
W.D. Xiao et al., "ADENOASSOCIATED VIRUS AS A VECTOR FOR LIVER-DIRECTED GENE-THERAPY", Journal of virology (Print), 72(12), 1998, pp. 10222-10226

Abstract

Factors relevant to the successful application of adeno-associated virus (AAV) vectors for liver-directed gene therapy were evaluated. Vectors with different promoters driving expression of human alpha-1-antitrypsin (alpha-1AT) were injected into the portal circulation of immunodeficient mice. a-1AT expression was stable but dependent on the promoter. Southern analysis of liver DNA revealed approximately 0.1 to 2.0 provirus copies/diploid genome in presumed head-to-tail concatamers. In situ hybridization and immunohistochemical analysis revealed expression in approximately 5% of hepatocytes clustered in the pericentral region. These results support the use of AAV as a vector for diseases treatable by targeting of hepatocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 14:57:13